Class: Regulation

name: regulation
description: Reified regulatory assertion linking a regulator physical entity to a
  regulated reaction-like event.
comments:
- Reactome models regulation explicitly instead of flattening it into a simple binary
  relation.
from_schema: https://w3id.org/reactome-ontology
is_a: database_object
abstract: true
slots:
- has_regulator
- regulates
- has_active_unit
- supported_by
slot_usage:
  has_regulator:
    name: has_regulator
    required: true
  regulates:
    name: regulates
    required: true
class_uri: reactome:Regulation

name: regulation
description: Reified regulatory assertion linking a regulator physical entity to a
  regulated reaction-like event.
comments:
- Reactome models regulation explicitly instead of flattening it into a simple binary
  relation.
from_schema: https://w3id.org/reactome-ontology
is_a: database_object
abstract: true
slot_usage:
  has_regulator:
    name: has_regulator
    required: true
  regulates:
    name: regulates
    required: true
attributes:
  has_regulator:
    name: has_regulator
    description: Physical entity that exerts regulatory influence on a regulated event.
    comments:
    - May be a protein, complex, small molecule, set, or other physical entity.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasRegulator
    alias: has_regulator
    owner: regulation
    domain_of:
    - regulation
    range: physical_entity
    required: true
    multivalued: false
  regulates:
    name: regulates
    description: Reaction-like event that is the target of regulation.
    comments:
    - Kept explicit through reified regulation nodes rather than flattened triples.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:regulates
    alias: regulates
    owner: regulation
    domain_of:
    - regulation
    range: reaction_like_event
    required: true
    multivalued: false
  has_active_unit:
    name: has_active_unit
    description: Subunit, domain-bearing fragment, or active molecular portion responsible
      for catalytic or regulatory activity.
    comments:
    - Reactome can attach active-unit detail to catalyst activities and regulation
      objects.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasActiveUnit
    alias: has_active_unit
    owner: regulation
    domain_of:
    - catalyst_activity
    - regulation
    range: physical_entity
    multivalued: true
    inlined: true
    inlined_as_list: true
  supported_by:
    name: supported_by
    description: Publication supporting the existence, mechanism, or curation of the
      object.
    comments:
    - Often points to PubMed-backed literature references.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:supportedBy
    alias: supported_by
    owner: regulation
    domain_of:
    - event
    - catalyst_activity
    - regulation
    range: publication
    multivalued: true
  reactome_db_id:
    name: reactome_db_id
    description: Internal Reactome database identifier assigned to a database object.
    comments:
    - Reactome DB_ID values are implementation-oriented identifiers rather than stable
      public identifiers.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:reactomeDbId
    alias: reactome_db_id
    owner: regulation
    domain_of:
    - database_object
    range: integer
    required: true
    multivalued: false
  reactome_stable_identifier:
    name: reactome_stable_identifier
    description: Stable public Reactome identifier for an object.
    comments:
    - Typically corresponds to the curated Reactome stable accession such as R-HSA-xxxxx.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:reactomeStableIdentifier
    alias: reactome_stable_identifier
    owner: regulation
    domain_of:
    - database_object
    range: string
    required: true
    multivalued: false
  source_schema_class:
    name: source_schema_class
    description: Name of the source Reactome schema class from which the instance
      derives.
    comments:
    - Useful when preserving frame-schema provenance or round-tripping with the original
      Reactome graph.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:sourceSchemaClass
    alias: source_schema_class
    owner: regulation
    domain_of:
    - database_object
    range: string
    required: true
    multivalued: false
  display_label:
    name: display_label
    description: Preferred display label used by Reactome for user-facing presentation.
    comments:
    - Often combines identity and contextual state into a concise label.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    is_a: name
    slot_uri: reactome:displayLabel
    alias: display_label
    owner: regulation
    domain_of:
    - database_object
    range: string
    required: true
    multivalued: false
  definition:
    name: definition
    description: Curated textual definition that states what the object is.
    comments:
    - Intended for conceptual definitions rather than narrative summaries.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:definition
    alias: definition
    owner: regulation
    domain_of:
    - database_object
    range: string
    multivalued: false
  previous_stable_identifier:
    name: previous_stable_identifier
    description: Deprecated or previous stable Reactome identifier retained for traceability.
    comments:
    - Useful during migration, identifier replacement, and legacy resolution.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:previousStableIdentifier
    alias: previous_stable_identifier
    owner: regulation
    domain_of:
    - database_object
    range: string
    multivalued: false
  created:
    name: created
    description: Provenance link to the curation event that originally created the
      object record.
    comments:
    - Usually points to an InstanceEdit containing editor and date metadata.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:created
    alias: created
    owner: regulation
    domain_of:
    - database_object
    range: instance_edit
    required: true
    multivalued: false
  modified:
    name: modified
    description: Provenance links to subsequent modifications of the object record.
    comments:
    - Multiple modifications are common across curation history.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:modified
    alias: modified
    owner: regulation
    domain_of:
    - database_object
    range: instance_edit
    multivalued: true
  id:
    name: id
    description: Unique identifier for an instance in the serialized dataset.
    comments:
    - This may be a local identifier, CURIE, URI, or other serialization key.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: dcterms:identifier
    identifier: true
    alias: id
    owner: regulation
    domain_of:
    - named_entity
    range: string
    required: true
  name:
    name: name
    description: Human-readable primary label for an object.
    comments:
    - Generic reusable naming slot for schema-wide use.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: rdfs:label
    alias: name
    owner: regulation
    domain_of:
    - named_entity
    range: string
  description:
    name: description
    description: Free-text textual description of an object.
    comments:
    - Can hold editorial notes, plain-language explanations, or short summaries.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: dcterms:description
    alias: description
    owner: regulation
    domain_of:
    - named_entity
    range: string
    multivalued: false
class_uri: reactome:Regulation