Class: BlackBoxEvent

name: black_box_event
description: Reaction-like event included in the pathway model despite incomplete
  mechanistic detail.
comments:
- Useful when biological evidence supports the event but not a full molecular mechanism.
from_schema: https://w3id.org/reactome-ontology
is_a: reaction_like_event
class_uri: reactome:BlackBoxEvent

name: black_box_event
description: Reaction-like event included in the pathway model despite incomplete
  mechanistic detail.
comments:
- Useful when biological evidence supports the event but not a full molecular mechanism.
from_schema: https://w3id.org/reactome-ontology
is_a: reaction_like_event
attributes:
  has_input:
    name: has_input
    description: Physical entity consumed, transformed, or otherwise used as an input
      to a reaction-like event.
    comments:
    - Inputs need not always be fully consumed in a strict stoichiometric sense across
      all event subclasses.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasInput
    alias: has_input
    owner: black_box_event
    domain_of:
    - reaction_like_event
    range: physical_entity
    multivalued: true
    inlined: true
    inlined_as_list: true
  has_output:
    name: has_output
    description: Physical entity produced by a reaction-like event.
    comments:
    - Output identity often reflects new compartment, modification state, or assembly
      state.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasOutput
    alias: has_output
    owner: black_box_event
    domain_of:
    - reaction_like_event
    range: physical_entity
    multivalued: true
    inlined: true
    inlined_as_list: true
  requires_component:
    name: requires_component
    description: Physical entity required for a reaction-like event but not modeled
      as a transforming input.
    comments:
    - Useful for contextual cofactors, platform components, or required participants.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:requiresComponent
    alias: requires_component
    owner: black_box_event
    domain_of:
    - reaction_like_event
    range: physical_entity
    multivalued: true
    inlined: true
    inlined_as_list: true
  has_catalyst_activity:
    name: has_catalyst_activity
    description: Catalyst activity associated with the reaction-like event.
    comments:
    - A central Reactome modeling pattern that preserves GO molecular function and
      active-unit context.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasCatalystActivity
    alias: has_catalyst_activity
    owner: black_box_event
    domain_of:
    - reaction_like_event
    range: catalyst_activity
    multivalued: true
    inlined: true
    inlined_as_list: true
  has_regulation:
    name: has_regulation
    description: Reified regulation assertion attached to an event.
    comments:
    - Supports positive, negative, and requirement-style regulatory semantics.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasRegulation
    alias: has_regulation
    owner: black_box_event
    domain_of:
    - reaction_like_event
    range: regulation
    multivalued: true
    inlined: true
    inlined_as_list: true
  preceded_by:
    name: preceded_by
    description: Event that occurs before the current event in a curated process sequence.
    comments:
    - Encodes partial ordering rather than necessarily strict temporal or causal completeness.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:precededBy
    alias: preceded_by
    owner: black_box_event
    domain_of:
    - reaction_like_event
    range: event
    multivalued: true
    inlined: true
    inlined_as_list: true
  has_interacting_entity_on_other_cell:
    name: has_interacting_entity_on_other_cell
    description: Physical entity located on another interacting cell in intercellular
      biology.
    comments:
    - Useful for immune, adhesion, and receptor-ligand interaction contexts.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasInteractingEntityOnOtherCell
    alias: has_interacting_entity_on_other_cell
    owner: black_box_event
    domain_of:
    - reaction_like_event
    range: physical_entity
    multivalued: true
    inlined: true
    inlined_as_list: true
  has_interaction:
    name: has_interaction
    description: Associated interaction object linked to an event.
    comments:
    - Preserves interaction-level detail when Reactome models such assertions explicitly.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasInteraction
    alias: has_interaction
    owner: black_box_event
    domain_of:
    - reaction_like_event
    range: interaction
    multivalued: true
    inlined: true
    inlined_as_list: true
  has_reaction_type:
    name: has_reaction_type
    description: Controlled reaction type annotation describing the mechanistic or
      editorial type of a reaction.
    comments:
    - Useful for grouping reaction-like events into broad mechanistic categories.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasReactionType
    alias: has_reaction_type
    owner: black_box_event
    domain_of:
    - reaction_like_event
    range: reaction_type_term
    multivalued: true
  in_taxon:
    name: in_taxon
    description: Taxon in which the object, event, or entity is asserted to occur
      or be defined.
    comments:
    - For events this denotes the organism context; for entities it denotes the biological
      source organism.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:inTaxon
    alias: in_taxon
    owner: black_box_event
    domain_of:
    - event
    - physical_entity
    range: organism_taxon
    multivalued: true
  located_in_compartment:
    name: located_in_compartment
    description: Compartment in which an entity resides or an event occurs.
    comments:
    - In Reactome, compartment is identity-relevant for many physical entities.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:locatedInCompartment
    alias: located_in_compartment
    owner: black_box_event
    domain_of:
    - event
    - physical_entity
    range: compartment
    multivalued: true
  has_summation:
    name: has_summation
    description: Narrative summary object explaining the biology of an event or entity.
    comments:
    - Distinct from formal definition; usually prose intended for readers.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasSummation
    alias: has_summation
    owner: black_box_event
    domain_of:
    - event
    range: summation
    multivalued: false
  has_cross_reference:
    name: has_cross_reference
    description: External cross-reference to another database or controlled resource.
    comments:
    - Used for interoperating with identifiers from GO, ChEBI, UniProt, Ensembl, and
      related resources.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasCrossReference
    alias: has_cross_reference
    owner: black_box_event
    domain_of:
    - event
    - physical_entity
    range: database_identifier
    multivalued: true
  has_disease_context:
    name: has_disease_context
    description: Disease context associated with an event or physical entity.
    comments:
    - Represents contextual disease association rather than broad etiologic modeling.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:hasDiseaseContext
    alias: has_disease_context
    owner: black_box_event
    domain_of:
    - event
    - physical_entity
    range: disease
    multivalued: true
  supported_by:
    name: supported_by
    description: Publication supporting the existence, mechanism, or curation of the
      object.
    comments:
    - Often points to PubMed-backed literature references.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:supportedBy
    alias: supported_by
    owner: black_box_event
    domain_of:
    - event
    - catalyst_activity
    - regulation
    range: publication
    multivalued: true
  reviewed:
    name: reviewed
    description: Provenance links to formal review actions on the object.
    comments:
    - Distinct from simple modification in Reactome curation workflows.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:reviewed
    alias: reviewed
    owner: black_box_event
    domain_of:
    - event
    range: instance_edit
    multivalued: true
  revised:
    name: revised
    description: Provenance links to explicit revision actions after prior curation
      or review.
    comments:
    - Useful for tracking editorial iteration.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:revised
    alias: revised
    owner: black_box_event
    domain_of:
    - event
    range: instance_edit
    multivalued: true
  release_date:
    name: release_date
    description: Release date associated with a curation or publication cycle.
    comments:
    - Modeled as string to match Reactome exports; can be normalized later if needed.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:releaseDate
    alias: release_date
    owner: black_box_event
    domain_of:
    - event
    range: date
    multivalued: false
  release_status:
    name: release_status
    description: Editorial release state of the object in the Reactome release process.
    comments:
    - Examples might include draft-like or released-like status labels depending on
      source exports.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:releaseStatus
    alias: release_status
    owner: black_box_event
    domain_of:
    - event
    range: string
    multivalued: false
  is_inferred:
    name: is_inferred
    description: Indicates whether an object was computationally inferred rather than
      directly curated.
    comments:
    - Reactome uses inference especially for orthology-based event propagation.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:isInferred
    alias: is_inferred
    owner: black_box_event
    domain_of:
    - event
    range: boolean
    multivalued: false
  reactome_db_id:
    name: reactome_db_id
    description: Internal Reactome database identifier assigned to a database object.
    comments:
    - Reactome DB_ID values are implementation-oriented identifiers rather than stable
      public identifiers.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:reactomeDbId
    alias: reactome_db_id
    owner: black_box_event
    domain_of:
    - database_object
    range: integer
    required: true
    multivalued: false
  reactome_stable_identifier:
    name: reactome_stable_identifier
    description: Stable public Reactome identifier for an object.
    comments:
    - Typically corresponds to the curated Reactome stable accession such as R-HSA-xxxxx.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:reactomeStableIdentifier
    alias: reactome_stable_identifier
    owner: black_box_event
    domain_of:
    - database_object
    range: string
    required: true
    multivalued: false
  source_schema_class:
    name: source_schema_class
    description: Name of the source Reactome schema class from which the instance
      derives.
    comments:
    - Useful when preserving frame-schema provenance or round-tripping with the original
      Reactome graph.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:sourceSchemaClass
    alias: source_schema_class
    owner: black_box_event
    domain_of:
    - database_object
    range: string
    required: true
    multivalued: false
  display_label:
    name: display_label
    description: Preferred display label used by Reactome for user-facing presentation.
    comments:
    - Often combines identity and contextual state into a concise label.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    is_a: name
    slot_uri: reactome:displayLabel
    alias: display_label
    owner: black_box_event
    domain_of:
    - database_object
    range: string
    required: true
    multivalued: false
  definition:
    name: definition
    description: Curated textual definition that states what the object is.
    comments:
    - Intended for conceptual definitions rather than narrative summaries.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:definition
    alias: definition
    owner: black_box_event
    domain_of:
    - database_object
    range: string
    multivalued: false
  previous_stable_identifier:
    name: previous_stable_identifier
    description: Deprecated or previous stable Reactome identifier retained for traceability.
    comments:
    - Useful during migration, identifier replacement, and legacy resolution.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:previousStableIdentifier
    alias: previous_stable_identifier
    owner: black_box_event
    domain_of:
    - database_object
    range: string
    multivalued: false
  created:
    name: created
    description: Provenance link to the curation event that originally created the
      object record.
    comments:
    - Usually points to an InstanceEdit containing editor and date metadata.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:created
    alias: created
    owner: black_box_event
    domain_of:
    - database_object
    range: instance_edit
    required: true
    multivalued: false
  modified:
    name: modified
    description: Provenance links to subsequent modifications of the object record.
    comments:
    - Multiple modifications are common across curation history.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: reactome:modified
    alias: modified
    owner: black_box_event
    domain_of:
    - database_object
    range: instance_edit
    multivalued: true
  id:
    name: id
    description: Unique identifier for an instance in the serialized dataset.
    comments:
    - This may be a local identifier, CURIE, URI, or other serialization key.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: dcterms:identifier
    identifier: true
    alias: id
    owner: black_box_event
    domain_of:
    - named_entity
    range: string
    required: true
  name:
    name: name
    description: Human-readable primary label for an object.
    comments:
    - Generic reusable naming slot for schema-wide use.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: rdfs:label
    alias: name
    owner: black_box_event
    domain_of:
    - named_entity
    range: string
  description:
    name: description
    description: Free-text textual description of an object.
    comments:
    - Can hold editorial notes, plain-language explanations, or short summaries.
    from_schema: https://w3id.org/reactome-ontology
    rank: 1000
    slot_uri: dcterms:description
    alias: description
    owner: black_box_event
    domain_of:
    - named_entity
    range: string
    multivalued: false
class_uri: reactome:BlackBoxEvent