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Class: ExposureDiseaseAssociation

Optional association for ExposureOrStressor -> Disease when epidemiology, mechanism, dose, duration, population, or study design metadata are needed. Materializes to exposure_associated_with_disease.

URI: alskb:ExposureDiseaseAssociation

 classDiagram
    class ExposureDiseaseAssociation
    click ExposureDiseaseAssociation href "../ExposureDiseaseAssociation/"
      Association <|-- ExposureDiseaseAssociation
        click Association href "../Association/"

      ExposureDiseaseAssociation : association_id

      ExposureDiseaseAssociation : association_label

      ExposureDiseaseAssociation : association_type

      ExposureDiseaseAssociation : confidence

      ExposureDiseaseAssociation : epidemiological_support

      ExposureDiseaseAssociation : evidence_source

      ExposureDiseaseAssociation : evidence_type

      ExposureDiseaseAssociation : exposure





        ExposureDiseaseAssociation --> "1" ExposureOrStressor : exposure
        click ExposureOrStressor href "../ExposureOrStressor/"



      ExposureDiseaseAssociation : has_disease





        ExposureDiseaseAssociation --> "1" Disease : has_disease
        click Disease href "../Disease/"



      ExposureDiseaseAssociation : ingest_date

      ExposureDiseaseAssociation : last_updated

      ExposureDiseaseAssociation : mechanism

      ExposureDiseaseAssociation : object

      ExposureDiseaseAssociation : odds_ratio

      ExposureDiseaseAssociation : population

      ExposureDiseaseAssociation : predicate

      ExposureDiseaseAssociation : source

      ExposureDiseaseAssociation : source_version

      ExposureDiseaseAssociation : subject

Inheritance

Slots

Name Cardinality and Range Description Inheritance
exposure 1
ExposureOrStressor		 direct
has_disease 1
Disease		 direct
predicate 0..1
String		 direct
association_type 0..1
String		 risk_factor, protective, trigger, modifier, or correlative direct
mechanism 0..1
String		 Proposed biological mechanism direct
epidemiological_support 0..1
Boolean		 direct
odds_ratio 0..1
Float		 Epidemiological odds ratio or equivalent effect estimate direct
population 0..1
String		 Population, geography, occupation, or cohort context direct
association_id 0..1
Uriorcurie		 Stable identifier for the association record Association
association_label 0..1
String		 Human-readable summary of the association Association
subject 1
String		 Subject entity IRI or CURIE used to materialize a direct edge Association, Relationship
object 1
String		 Object entity IRI or CURIE used to materialize a direct edge Association, Relationship
source 0..1
String		 Data source for this association Association, Relationship
source_version 0..1
String		 Data source version or release date Association
evidence_type 0..1
String		 Type of supporting evidence Association, Relationship
evidence_source 0..1
String		 Publication, study, database record, or extraction artifact supporting the as... Association, Relationship
confidence 0..1
String		 Normalized confidence score from 0 to 1 Association, Relationship
ingest_date 0..1
String		 Date this association was ingested Association, Relationship
last_updated 0..1
String		 Date this association was last modified Association

Identifier and Mapping Information

Schema Source

  • from schema: https://cair2015.github.io/als-kg

Mappings

Mapping Type Mapped Value
self alskb:ExposureDiseaseAssociation
native alskb:ExposureDiseaseAssociation

LinkML Source

Direct

name: ExposureDiseaseAssociation
description: Optional association for ExposureOrStressor -> Disease when epidemiology,
  mechanism, dose, duration, population, or study design metadata are needed. Materializes
  to exposure_associated_with_disease.
from_schema: https://cair2015.github.io/als-kg
is_a: Association
attributes:
  exposure:
    name: exposure
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - ExposureDiseaseAssociation
    range: ExposureOrStressor
    required: true
  has_disease:
    name: has_disease
    from_schema: https://cair2015.github.io/als-kg
    domain_of:
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    range: Disease
    required: true
  predicate:
    name: predicate
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:predicate
    ifabsent: alskb:exposure_associated_with_disease
    domain_of:
    - Relationship
    - Association
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - VariantProteinEffectAssociation
    - ProteinProteinInteractionAssociation
    - ProteinPathwayAssociation
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    - TranscriptionFactorRegulationAssociation
    - GeneExpressionAssociation
    - DiseaseDiseaseAssociation
  association_type:
    name: association_type
    description: risk_factor, protective, trigger, modifier, or correlative
    from_schema: https://cair2015.github.io/als-kg
    domain_of:
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - ExposureDiseaseAssociation
  mechanism:
    name: mechanism
    description: Proposed biological mechanism
    from_schema: https://cair2015.github.io/als-kg
    domain_of:
    - Drug
    - DrugTargetAssociation
    - ExposureDiseaseAssociation
  epidemiological_support:
    name: epidemiological_support
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - ExposureDiseaseAssociation
    range: boolean
  odds_ratio:
    name: odds_ratio
    description: Epidemiological odds ratio or equivalent effect estimate
    from_schema: https://cair2015.github.io/als-kg
    domain_of:
    - GeneDiseaseAssociation
    - ExposureDiseaseAssociation
    range: float
  population:
    name: population
    description: Population, geography, occupation, or cohort context
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - ExposureDiseaseAssociation

Induced

name: ExposureDiseaseAssociation
description: Optional association for ExposureOrStressor -> Disease when epidemiology,
  mechanism, dose, duration, population, or study design metadata are needed. Materializes
  to exposure_associated_with_disease.
from_schema: https://cair2015.github.io/als-kg
is_a: Association
attributes:
  exposure:
    name: exposure
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: exposure
    owner: ExposureDiseaseAssociation
    domain_of:
    - ExposureDiseaseAssociation
    range: ExposureOrStressor
    required: true
  has_disease:
    name: has_disease
    from_schema: https://cair2015.github.io/als-kg
    alias: has_disease
    owner: ExposureDiseaseAssociation
    domain_of:
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    range: Disease
    required: true
  predicate:
    name: predicate
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:predicate
    ifabsent: alskb:exposure_associated_with_disease
    alias: predicate
    owner: ExposureDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - VariantProteinEffectAssociation
    - ProteinProteinInteractionAssociation
    - ProteinPathwayAssociation
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    - TranscriptionFactorRegulationAssociation
    - GeneExpressionAssociation
    - DiseaseDiseaseAssociation
    range: string
  association_type:
    name: association_type
    description: risk_factor, protective, trigger, modifier, or correlative
    from_schema: https://cair2015.github.io/als-kg
    alias: association_type
    owner: ExposureDiseaseAssociation
    domain_of:
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - ExposureDiseaseAssociation
    range: string
  mechanism:
    name: mechanism
    description: Proposed biological mechanism
    from_schema: https://cair2015.github.io/als-kg
    alias: mechanism
    owner: ExposureDiseaseAssociation
    domain_of:
    - Drug
    - DrugTargetAssociation
    - ExposureDiseaseAssociation
    range: string
  epidemiological_support:
    name: epidemiological_support
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: epidemiological_support
    owner: ExposureDiseaseAssociation
    domain_of:
    - ExposureDiseaseAssociation
    range: boolean
  odds_ratio:
    name: odds_ratio
    description: Epidemiological odds ratio or equivalent effect estimate
    from_schema: https://cair2015.github.io/als-kg
    alias: odds_ratio
    owner: ExposureDiseaseAssociation
    domain_of:
    - GeneDiseaseAssociation
    - ExposureDiseaseAssociation
    range: float
  population:
    name: population
    description: Population, geography, occupation, or cohort context
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: population
    owner: ExposureDiseaseAssociation
    domain_of:
    - ExposureDiseaseAssociation
    range: string
  association_id:
    name: association_id
    description: Stable identifier for the association record
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    slot_uri: schema:identifier
    alias: association_id
    owner: ExposureDiseaseAssociation
    domain_of:
    - Association
    range: uriorcurie
  association_label:
    name: association_label
    description: Human-readable summary of the association
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    slot_uri: rdfs:label
    alias: association_label
    owner: ExposureDiseaseAssociation
    domain_of:
    - Association
    range: string
  subject:
    name: subject
    description: Subject entity IRI or CURIE used to materialize a direct edge
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:subject
    alias: subject
    owner: ExposureDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    range: string
    required: true
  object:
    name: object
    description: Object entity IRI or CURIE used to materialize a direct edge
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:object
    alias: object
    owner: ExposureDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    range: string
    required: true
  source:
    name: source
    description: Data source for this association
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:source
    alias: source
    owner: ExposureDiseaseAssociation
    domain_of:
    - NamedEntity
    - Relationship
    - Association
    range: string
  source_version:
    name: source_version
    description: Data source version or release date
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:hasVersion
    alias: source_version
    owner: ExposureDiseaseAssociation
    domain_of:
    - OntologyClass
    - Association
    range: string
  evidence_type:
    name: evidence_type
    description: Type of supporting evidence
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: ECO:0000000
    alias: evidence_type
    owner: ExposureDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  evidence_source:
    name: evidence_source
    description: Publication, study, database record, or extraction artifact supporting
      the association
    from_schema: https://cair2015.github.io/als-kg
    alias: evidence_source
    owner: ExposureDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  confidence:
    name: confidence
    description: Normalized confidence score from 0 to 1
    from_schema: https://cair2015.github.io/als-kg
    alias: confidence
    owner: ExposureDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  ingest_date:
    name: ingest_date
    description: Date this association was ingested
    from_schema: https://cair2015.github.io/als-kg
    alias: ingest_date
    owner: ExposureDiseaseAssociation
    domain_of:
    - OntologyClass
    - Relationship
    - Association
    range: string
  last_updated:
    name: last_updated
    description: Date this association was last modified
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:modified
    alias: last_updated
    owner: ExposureDiseaseAssociation
    domain_of:
    - NamedEntity
    - Association
    range: string