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Class: DrugTargetAssociation

Optional association for Drug -> MolecularEntity when action type, binding affinity, target class, or mechanism evidence is needed. Materializes to drug_targets_molecular_entity.

URI: alskb:DrugTargetAssociation

 classDiagram
    class DrugTargetAssociation
    click DrugTargetAssociation href "../DrugTargetAssociation/"
      Association <|-- DrugTargetAssociation
        click Association href "../Association/"

      DrugTargetAssociation : action_type

      DrugTargetAssociation : association_id

      DrugTargetAssociation : association_label

      DrugTargetAssociation : binding_affinity_nm

      DrugTargetAssociation : confidence

      DrugTargetAssociation : evidence_source

      DrugTargetAssociation : evidence_type

      DrugTargetAssociation : has_drug





        DrugTargetAssociation --> "1" Drug : has_drug
        click Drug href "../Drug/"



      DrugTargetAssociation : ingest_date

      DrugTargetAssociation : last_updated

      DrugTargetAssociation : mechanism

      DrugTargetAssociation : object

      DrugTargetAssociation : predicate

      DrugTargetAssociation : source

      DrugTargetAssociation : source_version

      DrugTargetAssociation : subject

      DrugTargetAssociation : target





        DrugTargetAssociation --> "1" MolecularEntity : target
        click MolecularEntity href "../MolecularEntity/"

Inheritance

Slots

Name Cardinality and Range Description Inheritance
has_drug 1
Drug		 direct
target 1
MolecularEntity		 Gene or protein target direct
predicate 0..1
String		 direct
action_type 0..1
String		 inhibitor, activator, binder, antagonist, agonist, modulator, ASO_knockdown, ... direct
binding_affinity_nm 0..1
Float		 Binding affinity in nanomolar when available direct
mechanism 0..1
String		 Mechanistic description of target modulation direct
association_id 0..1
Uriorcurie		 Stable identifier for the association record Association
association_label 0..1
String		 Human-readable summary of the association Association
subject 1
String		 Subject entity IRI or CURIE used to materialize a direct edge Association, Relationship
object 1
String		 Object entity IRI or CURIE used to materialize a direct edge Association, Relationship
source 0..1
String		 Data source for this association Association, Relationship
source_version 0..1
String		 Data source version or release date Association
evidence_type 0..1
String		 Type of supporting evidence Association, Relationship
evidence_source 0..1
String		 Publication, study, database record, or extraction artifact supporting the as... Association, Relationship
confidence 0..1
String		 Normalized confidence score from 0 to 1 Association, Relationship
ingest_date 0..1
String		 Date this association was ingested Association, Relationship
last_updated 0..1
String		 Date this association was last modified Association

Identifier and Mapping Information

Schema Source

  • from schema: https://cair2015.github.io/als-kg

Mappings

Mapping Type Mapped Value
self alskb:DrugTargetAssociation
native alskb:DrugTargetAssociation

LinkML Source

Direct

name: DrugTargetAssociation
description: Optional association for Drug -> MolecularEntity when action type, binding
  affinity, target class, or mechanism evidence is needed. Materializes to drug_targets_molecular_entity.
from_schema: https://cair2015.github.io/als-kg
is_a: Association
attributes:
  has_drug:
    name: has_drug
    from_schema: https://cair2015.github.io/als-kg
    domain_of:
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    range: Drug
    required: true
  target:
    name: target
    description: Gene or protein target
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - DrugTargetAssociation
    range: MolecularEntity
    required: true
  predicate:
    name: predicate
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:predicate
    ifabsent: alskb:drug_targets_molecular_entity
    domain_of:
    - Relationship
    - Association
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - VariantProteinEffectAssociation
    - ProteinProteinInteractionAssociation
    - ProteinPathwayAssociation
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    - TranscriptionFactorRegulationAssociation
    - GeneExpressionAssociation
    - DiseaseDiseaseAssociation
  action_type:
    name: action_type
    description: inhibitor, activator, binder, antagonist, agonist, modulator, ASO_knockdown,
      or unknown
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - DrugTargetAssociation
  binding_affinity_nm:
    name: binding_affinity_nm
    description: Binding affinity in nanomolar when available
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - DrugTargetAssociation
    range: float
  mechanism:
    name: mechanism
    description: Mechanistic description of target modulation
    from_schema: https://cair2015.github.io/als-kg
    domain_of:
    - Drug
    - DrugTargetAssociation
    - ExposureDiseaseAssociation

Induced

name: DrugTargetAssociation
description: Optional association for Drug -> MolecularEntity when action type, binding
  affinity, target class, or mechanism evidence is needed. Materializes to drug_targets_molecular_entity.
from_schema: https://cair2015.github.io/als-kg
is_a: Association
attributes:
  has_drug:
    name: has_drug
    from_schema: https://cair2015.github.io/als-kg
    alias: has_drug
    owner: DrugTargetAssociation
    domain_of:
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    range: Drug
    required: true
  target:
    name: target
    description: Gene or protein target
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: target
    owner: DrugTargetAssociation
    domain_of:
    - DrugTargetAssociation
    range: MolecularEntity
    required: true
  predicate:
    name: predicate
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:predicate
    ifabsent: alskb:drug_targets_molecular_entity
    alias: predicate
    owner: DrugTargetAssociation
    domain_of:
    - Relationship
    - Association
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - VariantProteinEffectAssociation
    - ProteinProteinInteractionAssociation
    - ProteinPathwayAssociation
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    - TranscriptionFactorRegulationAssociation
    - GeneExpressionAssociation
    - DiseaseDiseaseAssociation
    range: string
  action_type:
    name: action_type
    description: inhibitor, activator, binder, antagonist, agonist, modulator, ASO_knockdown,
      or unknown
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: action_type
    owner: DrugTargetAssociation
    domain_of:
    - DrugTargetAssociation
    range: string
  binding_affinity_nm:
    name: binding_affinity_nm
    description: Binding affinity in nanomolar when available
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: binding_affinity_nm
    owner: DrugTargetAssociation
    domain_of:
    - DrugTargetAssociation
    range: float
  mechanism:
    name: mechanism
    description: Mechanistic description of target modulation
    from_schema: https://cair2015.github.io/als-kg
    alias: mechanism
    owner: DrugTargetAssociation
    domain_of:
    - Drug
    - DrugTargetAssociation
    - ExposureDiseaseAssociation
    range: string
  association_id:
    name: association_id
    description: Stable identifier for the association record
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    slot_uri: schema:identifier
    alias: association_id
    owner: DrugTargetAssociation
    domain_of:
    - Association
    range: uriorcurie
  association_label:
    name: association_label
    description: Human-readable summary of the association
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    slot_uri: rdfs:label
    alias: association_label
    owner: DrugTargetAssociation
    domain_of:
    - Association
    range: string
  subject:
    name: subject
    description: Subject entity IRI or CURIE used to materialize a direct edge
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:subject
    alias: subject
    owner: DrugTargetAssociation
    domain_of:
    - Relationship
    - Association
    range: string
    required: true
  object:
    name: object
    description: Object entity IRI or CURIE used to materialize a direct edge
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:object
    alias: object
    owner: DrugTargetAssociation
    domain_of:
    - Relationship
    - Association
    range: string
    required: true
  source:
    name: source
    description: Data source for this association
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:source
    alias: source
    owner: DrugTargetAssociation
    domain_of:
    - NamedEntity
    - Relationship
    - Association
    range: string
  source_version:
    name: source_version
    description: Data source version or release date
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:hasVersion
    alias: source_version
    owner: DrugTargetAssociation
    domain_of:
    - OntologyClass
    - Association
    range: string
  evidence_type:
    name: evidence_type
    description: Type of supporting evidence
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: ECO:0000000
    alias: evidence_type
    owner: DrugTargetAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  evidence_source:
    name: evidence_source
    description: Publication, study, database record, or extraction artifact supporting
      the association
    from_schema: https://cair2015.github.io/als-kg
    alias: evidence_source
    owner: DrugTargetAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  confidence:
    name: confidence
    description: Normalized confidence score from 0 to 1
    from_schema: https://cair2015.github.io/als-kg
    alias: confidence
    owner: DrugTargetAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  ingest_date:
    name: ingest_date
    description: Date this association was ingested
    from_schema: https://cair2015.github.io/als-kg
    alias: ingest_date
    owner: DrugTargetAssociation
    domain_of:
    - OntologyClass
    - Relationship
    - Association
    range: string
  last_updated:
    name: last_updated
    description: Date this association was last modified
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:modified
    alias: last_updated
    owner: DrugTargetAssociation
    domain_of:
    - NamedEntity
    - Association
    range: string