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Class: DrugDiseaseTherapeuticAssociation

Optional association for Drug -> Disease when therapeutic indication, approval status, clinical-trial evidence, or outcome metadata are needed. Materializes to drug_treats_or_modulates_disease.

URI: alskb:DrugDiseaseTherapeuticAssociation

 classDiagram
    class DrugDiseaseTherapeuticAssociation
    click DrugDiseaseTherapeuticAssociation href "../DrugDiseaseTherapeuticAssociation/"
      Association <|-- DrugDiseaseTherapeuticAssociation
        click Association href "../Association/"

      DrugDiseaseTherapeuticAssociation : approval_status

      DrugDiseaseTherapeuticAssociation : association_id

      DrugDiseaseTherapeuticAssociation : association_label

      DrugDiseaseTherapeuticAssociation : clinical_phase

      DrugDiseaseTherapeuticAssociation : confidence

      DrugDiseaseTherapeuticAssociation : evidence_source

      DrugDiseaseTherapeuticAssociation : evidence_type

      DrugDiseaseTherapeuticAssociation : has_disease





        DrugDiseaseTherapeuticAssociation --> "1" Disease : has_disease
        click Disease href "../Disease/"



      DrugDiseaseTherapeuticAssociation : has_drug





        DrugDiseaseTherapeuticAssociation --> "1" Drug : has_drug
        click Drug href "../Drug/"



      DrugDiseaseTherapeuticAssociation : ingest_date

      DrugDiseaseTherapeuticAssociation : last_updated

      DrugDiseaseTherapeuticAssociation : object

      DrugDiseaseTherapeuticAssociation : outcome_measure

      DrugDiseaseTherapeuticAssociation : predicate

      DrugDiseaseTherapeuticAssociation : relation_type

      DrugDiseaseTherapeuticAssociation : source

      DrugDiseaseTherapeuticAssociation : source_version

      DrugDiseaseTherapeuticAssociation : subject

Inheritance

Slots

Name Cardinality and Range Description Inheritance
has_drug 1
Drug		 direct
has_disease 1
Disease		 direct
predicate 0..1
String		 direct
relation_type 0..1
String		 treats, disease_modifying, symptomatic, palliative, contraindicated, off_labe... direct
approval_status 0..1
String		 approved, investigational, withdrawn, off_label, failed_trial, or unknown direct
clinical_phase 0..1
String		 Highest clinical development phase for ALS or ALS subtype direct
outcome_measure 0..1
String		 ALSFRS-R, survival, respiratory function, biomarker, or other endpoint direct
association_id 0..1
Uriorcurie		 Stable identifier for the association record Association
association_label 0..1
String		 Human-readable summary of the association Association
subject 1
String		 Subject entity IRI or CURIE used to materialize a direct edge Association, Relationship
object 1
String		 Object entity IRI or CURIE used to materialize a direct edge Association, Relationship
source 0..1
String		 Data source for this association Association, Relationship
source_version 0..1
String		 Data source version or release date Association
evidence_type 0..1
String		 Type of supporting evidence Association, Relationship
evidence_source 0..1
String		 Publication, study, database record, or extraction artifact supporting the as... Association, Relationship
confidence 0..1
String		 Normalized confidence score from 0 to 1 Association, Relationship
ingest_date 0..1
String		 Date this association was ingested Association, Relationship
last_updated 0..1
String		 Date this association was last modified Association

Identifier and Mapping Information

Schema Source

  • from schema: https://cair2015.github.io/als-kg

Mappings

Mapping Type Mapped Value
self alskb:DrugDiseaseTherapeuticAssociation
native alskb:DrugDiseaseTherapeuticAssociation

LinkML Source

Direct

name: DrugDiseaseTherapeuticAssociation
description: Optional association for Drug -> Disease when therapeutic indication,
  approval status, clinical-trial evidence, or outcome metadata are needed. Materializes
  to drug_treats_or_modulates_disease.
from_schema: https://cair2015.github.io/als-kg
is_a: Association
attributes:
  has_drug:
    name: has_drug
    from_schema: https://cair2015.github.io/als-kg
    domain_of:
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    range: Drug
    required: true
  has_disease:
    name: has_disease
    from_schema: https://cair2015.github.io/als-kg
    domain_of:
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    range: Disease
    required: true
  predicate:
    name: predicate
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:predicate
    ifabsent: alskb:drug_treats_or_modulates_disease
    domain_of:
    - Relationship
    - Association
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - VariantProteinEffectAssociation
    - ProteinProteinInteractionAssociation
    - ProteinPathwayAssociation
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    - TranscriptionFactorRegulationAssociation
    - GeneExpressionAssociation
    - DiseaseDiseaseAssociation
  relation_type:
    name: relation_type
    description: treats, disease_modifying, symptomatic, palliative, contraindicated,
      off_label, or investigational
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - DrugDiseaseTherapeuticAssociation
    - DiseaseDiseaseAssociation
  approval_status:
    name: approval_status
    description: approved, investigational, withdrawn, off_label, failed_trial, or
      unknown
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - DrugDiseaseTherapeuticAssociation
  clinical_phase:
    name: clinical_phase
    description: Highest clinical development phase for ALS or ALS subtype
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - DrugDiseaseTherapeuticAssociation
  outcome_measure:
    name: outcome_measure
    description: ALSFRS-R, survival, respiratory function, biomarker, or other endpoint
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - DrugDiseaseTherapeuticAssociation

Induced

name: DrugDiseaseTherapeuticAssociation
description: Optional association for Drug -> Disease when therapeutic indication,
  approval status, clinical-trial evidence, or outcome metadata are needed. Materializes
  to drug_treats_or_modulates_disease.
from_schema: https://cair2015.github.io/als-kg
is_a: Association
attributes:
  has_drug:
    name: has_drug
    from_schema: https://cair2015.github.io/als-kg
    alias: has_drug
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    range: Drug
    required: true
  has_disease:
    name: has_disease
    from_schema: https://cair2015.github.io/als-kg
    alias: has_disease
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    range: Disease
    required: true
  predicate:
    name: predicate
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:predicate
    ifabsent: alskb:drug_treats_or_modulates_disease
    alias: predicate
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - Relationship
    - Association
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - VariantProteinEffectAssociation
    - ProteinProteinInteractionAssociation
    - ProteinPathwayAssociation
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    - TranscriptionFactorRegulationAssociation
    - GeneExpressionAssociation
    - DiseaseDiseaseAssociation
    range: string
  relation_type:
    name: relation_type
    description: treats, disease_modifying, symptomatic, palliative, contraindicated,
      off_label, or investigational
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: relation_type
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - DrugDiseaseTherapeuticAssociation
    - DiseaseDiseaseAssociation
    range: string
  approval_status:
    name: approval_status
    description: approved, investigational, withdrawn, off_label, failed_trial, or
      unknown
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: approval_status
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - DrugDiseaseTherapeuticAssociation
    range: string
  clinical_phase:
    name: clinical_phase
    description: Highest clinical development phase for ALS or ALS subtype
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: clinical_phase
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - DrugDiseaseTherapeuticAssociation
    range: string
  outcome_measure:
    name: outcome_measure
    description: ALSFRS-R, survival, respiratory function, biomarker, or other endpoint
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: outcome_measure
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - DrugDiseaseTherapeuticAssociation
    range: string
  association_id:
    name: association_id
    description: Stable identifier for the association record
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    slot_uri: schema:identifier
    alias: association_id
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - Association
    range: uriorcurie
  association_label:
    name: association_label
    description: Human-readable summary of the association
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    slot_uri: rdfs:label
    alias: association_label
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - Association
    range: string
  subject:
    name: subject
    description: Subject entity IRI or CURIE used to materialize a direct edge
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:subject
    alias: subject
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - Relationship
    - Association
    range: string
    required: true
  object:
    name: object
    description: Object entity IRI or CURIE used to materialize a direct edge
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:object
    alias: object
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - Relationship
    - Association
    range: string
    required: true
  source:
    name: source
    description: Data source for this association
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:source
    alias: source
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - NamedEntity
    - Relationship
    - Association
    range: string
  source_version:
    name: source_version
    description: Data source version or release date
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:hasVersion
    alias: source_version
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - OntologyClass
    - Association
    range: string
  evidence_type:
    name: evidence_type
    description: Type of supporting evidence
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: ECO:0000000
    alias: evidence_type
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  evidence_source:
    name: evidence_source
    description: Publication, study, database record, or extraction artifact supporting
      the association
    from_schema: https://cair2015.github.io/als-kg
    alias: evidence_source
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  confidence:
    name: confidence
    description: Normalized confidence score from 0 to 1
    from_schema: https://cair2015.github.io/als-kg
    alias: confidence
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  ingest_date:
    name: ingest_date
    description: Date this association was ingested
    from_schema: https://cair2015.github.io/als-kg
    alias: ingest_date
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - OntologyClass
    - Relationship
    - Association
    range: string
  last_updated:
    name: last_updated
    description: Date this association was last modified
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:modified
    alias: last_updated
    owner: DrugDiseaseTherapeuticAssociation
    domain_of:
    - NamedEntity
    - Association
    range: string