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Class: DiseaseDiseaseAssociation

Optional association for Disease -> Disease when disease-disease edges need relation type, similarity score, shared mechanism, or comorbidity statistics. Materializes to disease_related_to_disease.

URI: alskb:DiseaseDiseaseAssociation

 classDiagram
    class DiseaseDiseaseAssociation
    click DiseaseDiseaseAssociation href "../DiseaseDiseaseAssociation/"
      Association <|-- DiseaseDiseaseAssociation
        click Association href "../Association/"

      DiseaseDiseaseAssociation : association_id

      DiseaseDiseaseAssociation : association_label

      DiseaseDiseaseAssociation : confidence

      DiseaseDiseaseAssociation : disease_1





        DiseaseDiseaseAssociation --> "1" Disease : disease_1
        click Disease href "../Disease/"



      DiseaseDiseaseAssociation : disease_2





        DiseaseDiseaseAssociation --> "1" Disease : disease_2
        click Disease href "../Disease/"



      DiseaseDiseaseAssociation : evidence_source

      DiseaseDiseaseAssociation : evidence_type

      DiseaseDiseaseAssociation : ingest_date

      DiseaseDiseaseAssociation : last_updated

      DiseaseDiseaseAssociation : object

      DiseaseDiseaseAssociation : predicate

      DiseaseDiseaseAssociation : relation_type

      DiseaseDiseaseAssociation : shared_mechanism

      DiseaseDiseaseAssociation : similarity_score

      DiseaseDiseaseAssociation : source

      DiseaseDiseaseAssociation : source_version

      DiseaseDiseaseAssociation : subject

Inheritance

Slots

Name Cardinality and Range Description Inheritance
disease_1 1
Disease		 direct
disease_2 1
Disease		 direct
predicate 0..1
String		 direct
relation_type 0..1
String		 comorbidity, shared_pathway, shared_gene, phenotypic_similarity, differential... direct
similarity_score 0..1
Float		 Semantic similarity or clinical overlap score from 0 to 1 direct
shared_mechanism 0..1
String		 Shared biological mechanism, pathway, or clinical rationale direct
association_id 0..1
Uriorcurie		 Stable identifier for the association record Association
association_label 0..1
String		 Human-readable summary of the association Association
subject 1
String		 Subject entity IRI or CURIE used to materialize a direct edge Association, Relationship
object 1
String		 Object entity IRI or CURIE used to materialize a direct edge Association, Relationship
source 0..1
String		 Data source for this association Association, Relationship
source_version 0..1
String		 Data source version or release date Association
evidence_type 0..1
String		 Type of supporting evidence Association, Relationship
evidence_source 0..1
String		 Publication, study, database record, or extraction artifact supporting the as... Association, Relationship
confidence 0..1
String		 Normalized confidence score from 0 to 1 Association, Relationship
ingest_date 0..1
String		 Date this association was ingested Association, Relationship
last_updated 0..1
String		 Date this association was last modified Association

Identifier and Mapping Information

Schema Source

  • from schema: https://cair2015.github.io/als-kg

Mappings

Mapping Type Mapped Value
self alskb:DiseaseDiseaseAssociation
native alskb:DiseaseDiseaseAssociation

LinkML Source

Direct

name: DiseaseDiseaseAssociation
description: Optional association for Disease -> Disease when disease-disease edges
  need relation type, similarity score, shared mechanism, or comorbidity statistics.
  Materializes to disease_related_to_disease.
from_schema: https://cair2015.github.io/als-kg
is_a: Association
attributes:
  disease_1:
    name: disease_1
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - DiseaseDiseaseAssociation
    range: Disease
    required: true
  disease_2:
    name: disease_2
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - DiseaseDiseaseAssociation
    range: Disease
    required: true
  predicate:
    name: predicate
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:predicate
    ifabsent: alskb:disease_related_to_disease
    domain_of:
    - Relationship
    - Association
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - VariantProteinEffectAssociation
    - ProteinProteinInteractionAssociation
    - ProteinPathwayAssociation
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    - TranscriptionFactorRegulationAssociation
    - GeneExpressionAssociation
    - DiseaseDiseaseAssociation
  relation_type:
    name: relation_type
    description: comorbidity, shared_pathway, shared_gene, phenotypic_similarity,
      differential_diagnosis, or disease_subtype
    from_schema: https://cair2015.github.io/als-kg
    domain_of:
    - DrugDiseaseTherapeuticAssociation
    - DiseaseDiseaseAssociation
  similarity_score:
    name: similarity_score
    description: Semantic similarity or clinical overlap score from 0 to 1
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - DiseaseDiseaseAssociation
    range: float
  shared_mechanism:
    name: shared_mechanism
    description: Shared biological mechanism, pathway, or clinical rationale
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    domain_of:
    - DiseaseDiseaseAssociation

Induced

name: DiseaseDiseaseAssociation
description: Optional association for Disease -> Disease when disease-disease edges
  need relation type, similarity score, shared mechanism, or comorbidity statistics.
  Materializes to disease_related_to_disease.
from_schema: https://cair2015.github.io/als-kg
is_a: Association
attributes:
  disease_1:
    name: disease_1
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: disease_1
    owner: DiseaseDiseaseAssociation
    domain_of:
    - DiseaseDiseaseAssociation
    range: Disease
    required: true
  disease_2:
    name: disease_2
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: disease_2
    owner: DiseaseDiseaseAssociation
    domain_of:
    - DiseaseDiseaseAssociation
    range: Disease
    required: true
  predicate:
    name: predicate
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:predicate
    ifabsent: alskb:disease_related_to_disease
    alias: predicate
    owner: DiseaseDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    - DiseasePhenotypeAssociation
    - GeneDiseaseAssociation
    - VariantDiseaseAssociation
    - VariantProteinEffectAssociation
    - ProteinProteinInteractionAssociation
    - ProteinPathwayAssociation
    - DrugTargetAssociation
    - DrugDiseaseTherapeuticAssociation
    - ExposureDiseaseAssociation
    - TranscriptionFactorRegulationAssociation
    - GeneExpressionAssociation
    - DiseaseDiseaseAssociation
    range: string
  relation_type:
    name: relation_type
    description: comorbidity, shared_pathway, shared_gene, phenotypic_similarity,
      differential_diagnosis, or disease_subtype
    from_schema: https://cair2015.github.io/als-kg
    alias: relation_type
    owner: DiseaseDiseaseAssociation
    domain_of:
    - DrugDiseaseTherapeuticAssociation
    - DiseaseDiseaseAssociation
    range: string
  similarity_score:
    name: similarity_score
    description: Semantic similarity or clinical overlap score from 0 to 1
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: similarity_score
    owner: DiseaseDiseaseAssociation
    domain_of:
    - DiseaseDiseaseAssociation
    range: float
  shared_mechanism:
    name: shared_mechanism
    description: Shared biological mechanism, pathway, or clinical rationale
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    alias: shared_mechanism
    owner: DiseaseDiseaseAssociation
    domain_of:
    - DiseaseDiseaseAssociation
    range: string
  association_id:
    name: association_id
    description: Stable identifier for the association record
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    slot_uri: schema:identifier
    alias: association_id
    owner: DiseaseDiseaseAssociation
    domain_of:
    - Association
    range: uriorcurie
  association_label:
    name: association_label
    description: Human-readable summary of the association
    from_schema: https://cair2015.github.io/als-kg
    rank: 1000
    slot_uri: rdfs:label
    alias: association_label
    owner: DiseaseDiseaseAssociation
    domain_of:
    - Association
    range: string
  subject:
    name: subject
    description: Subject entity IRI or CURIE used to materialize a direct edge
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:subject
    alias: subject
    owner: DiseaseDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    range: string
    required: true
  object:
    name: object
    description: Object entity IRI or CURIE used to materialize a direct edge
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: rdf:object
    alias: object
    owner: DiseaseDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    range: string
    required: true
  source:
    name: source
    description: Data source for this association
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:source
    alias: source
    owner: DiseaseDiseaseAssociation
    domain_of:
    - NamedEntity
    - Relationship
    - Association
    range: string
  source_version:
    name: source_version
    description: Data source version or release date
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:hasVersion
    alias: source_version
    owner: DiseaseDiseaseAssociation
    domain_of:
    - OntologyClass
    - Association
    range: string
  evidence_type:
    name: evidence_type
    description: Type of supporting evidence
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: ECO:0000000
    alias: evidence_type
    owner: DiseaseDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  evidence_source:
    name: evidence_source
    description: Publication, study, database record, or extraction artifact supporting
      the association
    from_schema: https://cair2015.github.io/als-kg
    alias: evidence_source
    owner: DiseaseDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  confidence:
    name: confidence
    description: Normalized confidence score from 0 to 1
    from_schema: https://cair2015.github.io/als-kg
    alias: confidence
    owner: DiseaseDiseaseAssociation
    domain_of:
    - Relationship
    - Association
    range: string
  ingest_date:
    name: ingest_date
    description: Date this association was ingested
    from_schema: https://cair2015.github.io/als-kg
    alias: ingest_date
    owner: DiseaseDiseaseAssociation
    domain_of:
    - OntologyClass
    - Relationship
    - Association
    range: string
  last_updated:
    name: last_updated
    description: Date this association was last modified
    from_schema: https://cair2015.github.io/als-kg
    slot_uri: dcterms:modified
    alias: last_updated
    owner: DiseaseDiseaseAssociation
    domain_of:
    - NamedEntity
    - Association
    range: string