BlackBoxEvent
type: NodeShape
comment: Reaction-like event included in the pathway model despite incomplete mechanistic detail.
closed: true
ignored properties: type
property:
  class: ReactionTypeTerm
  description: Controlled reaction type annotation describing the mechanistic or editorial type of a reaction.
  node kind: IRI
  order: 8
  path: hasReactionType
property:
  class: PhysicalEntity
  description: Physical entity required for a reaction-like event but not modeled as a transforming input.
  node kind: IRI
  order: 2
  path: requiresComponent
property:
  class: PhysicalEntity
  description: Physical entity located on another interacting cell in intercellular biology.
  node kind: IRI
  order: 6
  path: hasInteractingEntityOnOtherCell
property:
  class: Event
  description: Event that occurs before the current event in a curated process sequence.
  node kind: IRI
  order: 5
  path: precededBy
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 12
  path: hasCrossReference
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 30
  path: description
property:
  class: Interaction
  description: Associated interaction object linked to an event.
  node kind: IRI
  order: 7
  path: hasInteraction
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 14
  path: supportedBy
property:
  class: InstanceEdit
  description: Provenance links to explicit revision actions after prior curation or review.
  node kind: IRI
  order: 16
  path: revised
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 23
  path: displayLabel
property:
  class: Summation
  description: Narrative summary object explaining the biology of an event or entity.
  max count: 1
  node kind: IRI
  order: 11
  path: hasSummation
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 27
  path: modified
property:
  class: PhysicalEntity
  description: Physical entity produced by a reaction-like event.
  node kind: IRI
  order: 1
  path: hasOutput
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 24
  path: definition
property:
  class: Regulation
  description: Reified regulation assertion attached to an event.
  node kind: IRI
  order: 4
  path: hasRegulation
property:
  datatype: date
  description: Release date associated with a curation or publication cycle.
  max count: 1
  node kind: Literal
  order: 17
  path: releaseDate
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 10
  path: locatedInCompartment
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 20
  path: reactomeDbId
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 28
  path: identifier
property:
  class: InstanceEdit
  description: Provenance links to formal review actions on the object.
  node kind: IRI
  order: 15
  path: reviewed
property:
  datatype: boolean
  description: Indicates whether an object was computationally inferred rather than directly curated.
  max count: 1
  node kind: Literal
  order: 19
  path: isInferred
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 21
  path: reactomeStableIdentifier
property:
  class: CatalystActivity
  description: Catalyst activity associated with the reaction-like event.
  node kind: IRI
  order: 3
  path: hasCatalystActivity
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 13
  path: hasDiseaseContext
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 29
  path: label
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 22
  path: sourceSchemaClass
property:
  datatype: string
  description: Editorial release state of the object in the Reactome release process.
  max count: 1
  node kind: Literal
  order: 18
  path: releaseStatus
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 26
  path: created
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 9
  path: inTaxon
property:
  class: PhysicalEntity
  description: Physical entity consumed, transformed, or otherwise used as an input to a reaction-like event.
  node kind: IRI
  order: 0
  path: hasInput

CandidateSet
type: NodeShape
comment: Entity set whose members are candidates for fulfilling a shared biological role.
closed: true
ignored properties: type
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 2
  path: locatedInCompartment
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 14
  path: created
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 16
  path: identifier
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 4
  path: hasDiseaseContext
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 1
  path: inTaxon
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 17
  path: label
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 3
  path: hasCrossReference
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: sourceSchemaClass
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 18
  path: description
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 6
  path: systematicName
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 12
  path: definition
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 11
  path: displayLabel
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 15
  path: modified
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 13
  path: previousStableIdentifier
property:
  class: PhysicalEntity
  description: Members of an entity set representing functionally interchangeable participants.
  min count: 1
  node kind: IRI
  order: 0
  path: hasMember
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 5
  path: hasGoCellularComponent
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 7
  path: isInDiseaseContext
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeDbId

Cell
type: NodeShape
comment: Cell or cell-like biological unit treated as a physical participant in an event.
closed: true
ignored properties: type
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 1
  path: locatedInCompartment
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: displayLabel
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 3
  path: hasDiseaseContext
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 0
  path: inTaxon
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 5
  path: systematicName
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 16
  path: label
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 12
  path: previousStableIdentifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 14
  path: modified
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 6
  path: isInDiseaseContext
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 11
  path: definition
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 13
  path: created
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 15
  path: identifier
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 2
  path: hasCrossReference
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 4
  path: hasGoCellularComponent
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: sourceSchemaClass
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 17
  path: description
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: reactomeDbId

ChemicalDrug
type: NodeShape
comment: Drug represented primarily as a chemical or small-molecule therapeutic agent.
closed: true
ignored properties: type
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeStableIdentifier
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 13
  path: created
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 6
  path: isInDiseaseContext
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 3
  path: hasDiseaseContext
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 11
  path: definition
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 15
  path: identifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 14
  path: modified
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 12
  path: previousStableIdentifier
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: displayLabel
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: sourceSchemaClass
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 16
  path: label
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 17
  path: description
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 1
  path: locatedInCompartment
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 5
  path: systematicName
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 4
  path: hasGoCellularComponent
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 2
  path: hasCrossReference
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 0
  path: inTaxon
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: reactomeDbId

Complex
type: NodeShape
comment: Physical entity composed of two or more component physical entities assembled into a functional complex.
closed: true
ignored properties: type
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 1
  path: inTaxon
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 16
  path: identifier
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 6
  path: systematicName
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 7
  path: isInDiseaseContext
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: reactomeStableIdentifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 15
  path: modified
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 14
  path: created
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 12
  path: definition
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: sourceSchemaClass
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 4
  path: hasDiseaseContext
property:
  class: PhysicalEntity
  description: Component physical entities that make up a complex.
  min count: 1
  node kind: IRI
  order: 0
  path: hasComponent
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 2
  path: locatedInCompartment
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeDbId
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 5
  path: hasGoCellularComponent
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 3
  path: hasCrossReference
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 18
  path: description
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 13
  path: previousStableIdentifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 17
  path: label
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 11
  path: displayLabel

DefinedSet
type: NodeShape
comment: Entity set whose members are explicitly curated as the intended interchangeable participants.
closed: true
ignored properties: type
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 14
  path: created
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 6
  path: systematicName
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeDbId
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 3
  path: hasCrossReference
property:
  class: PhysicalEntity
  description: Members of an entity set representing functionally interchangeable participants.
  min count: 1
  node kind: IRI
  order: 0
  path: hasMember
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 11
  path: displayLabel
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 1
  path: inTaxon
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 12
  path: definition
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 5
  path: hasGoCellularComponent
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 7
  path: isInDiseaseContext
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 13
  path: previousStableIdentifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 18
  path: description
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 17
  path: label
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 16
  path: identifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 15
  path: modified
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 2
  path: locatedInCompartment
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: sourceSchemaClass
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 4
  path: hasDiseaseContext

Depolymerization
type: NodeShape
comment: Event representing breakdown of a polymer into constituent or smaller units.
closed: true
ignored properties: type
property:
  datatype: date
  description: Release date associated with a curation or publication cycle.
  max count: 1
  node kind: Literal
  order: 17
  path: releaseDate
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 13
  path: hasDiseaseContext
property:
  class: PhysicalEntity
  description: Physical entity consumed, transformed, or otherwise used as an input to a reaction-like event.
  node kind: IRI
  order: 0
  path: hasInput
property:
  datatype: boolean
  description: Indicates whether an object was computationally inferred rather than directly curated.
  max count: 1
  node kind: Literal
  order: 19
  path: isInferred
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 12
  path: hasCrossReference
property:
  class: InstanceEdit
  description: Provenance links to formal review actions on the object.
  node kind: IRI
  order: 15
  path: reviewed
property:
  class: PhysicalEntity
  description: Physical entity required for a reaction-like event but not modeled as a transforming input.
  node kind: IRI
  order: 2
  path: requiresComponent
property:
  class: InstanceEdit
  description: Provenance links to explicit revision actions after prior curation or review.
  node kind: IRI
  order: 16
  path: revised
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 30
  path: description
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 23
  path: displayLabel
property:
  class: PhysicalEntity
  description: Physical entity produced by a reaction-like event.
  node kind: IRI
  order: 1
  path: hasOutput
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 14
  path: supportedBy
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 28
  path: identifier
property:
  class: Event
  description: Event that occurs before the current event in a curated process sequence.
  node kind: IRI
  order: 5
  path: precededBy
property:
  class: CatalystActivity
  description: Catalyst activity associated with the reaction-like event.
  node kind: IRI
  order: 3
  path: hasCatalystActivity
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 9
  path: inTaxon
property:
  class: Interaction
  description: Associated interaction object linked to an event.
  node kind: IRI
  order: 7
  path: hasInteraction
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 27
  path: modified
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 24
  path: definition
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 10
  path: locatedInCompartment
property:
  class: ReactionTypeTerm
  description: Controlled reaction type annotation describing the mechanistic or editorial type of a reaction.
  node kind: IRI
  order: 8
  path: hasReactionType
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 26
  path: created
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 21
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 29
  path: label
property:
  class: Summation
  description: Narrative summary object explaining the biology of an event or entity.
  max count: 1
  node kind: IRI
  order: 11
  path: hasSummation
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 20
  path: reactomeDbId
property:
  class: PhysicalEntity
  description: Physical entity located on another interacting cell in intercellular biology.
  node kind: IRI
  order: 6
  path: hasInteractingEntityOnOtherCell
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 25
  path: previousStableIdentifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 22
  path: sourceSchemaClass
property:
  datatype: string
  description: Editorial release state of the object in the Reactome release process.
  max count: 1
  node kind: Literal
  order: 18
  path: releaseStatus

Drug
type: NodeShape
comment: Therapeutic or intervention-oriented physical entity modeled in the Reactome graph.
closed: true
ignored properties: type
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 11
  path: definition
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 12
  path: previousStableIdentifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: reactomeDbId
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 4
  path: hasGoCellularComponent
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 0
  path: inTaxon
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 6
  path: isInDiseaseContext
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 2
  path: hasCrossReference
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 1
  path: locatedInCompartment
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 14
  path: modified
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: sourceSchemaClass
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 16
  path: label
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 5
  path: systematicName
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeStableIdentifier
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 13
  path: created
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 3
  path: hasDiseaseContext
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: displayLabel
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 15
  path: identifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 17
  path: description

EntitySet
type: NodeShape
comment: Curated set of physical entities that are treated as functionally interchangeable in a given biological context.
closed: true
ignored properties: type
property:
  class: PhysicalEntity
  description: Members of an entity set representing functionally interchangeable participants.
  min count: 1
  node kind: IRI
  order: 0
  path: hasMember
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 2
  path: locatedInCompartment
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 4
  path: hasDiseaseContext
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: sourceSchemaClass
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 16
  path: identifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 17
  path: label
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: reactomeStableIdentifier
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 7
  path: isInDiseaseContext
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 14
  path: created
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 13
  path: previousStableIdentifier
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 11
  path: displayLabel
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 3
  path: hasCrossReference
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 6
  path: systematicName
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 12
  path: definition
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 5
  path: hasGoCellularComponent
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 18
  path: description
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeDbId
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 1
  path: inTaxon
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 15
  path: modified

GenomeEncodedEntity
type: NodeShape
comment: Physical entity whose existence is grounded in a genome-encoded product such as a protein or nucleic acid.
closed: true
ignored properties: endCoordinate
ignored properties: hasReferenceEntity
ignored properties: type
ignored properties: sequenceReferenceType
ignored properties: startCoordinate
ignored properties: hasModifiedResidue
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 1
  path: locatedInCompartment
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 0
  path: inTaxon
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: reactomeDbId
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 16
  path: label
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 4
  path: hasGoCellularComponent
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: sourceSchemaClass
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 15
  path: identifier
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 5
  path: systematicName
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 13
  path: created
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 6
  path: isInDiseaseContext
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 3
  path: hasDiseaseContext
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 2
  path: hasCrossReference
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 11
  path: definition
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 17
  path: description
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: displayLabel
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 14
  path: modified
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 12
  path: previousStableIdentifier

LiteratureReference
type: NodeShape
comment: Literature citation record, commonly representing a PubMed-indexed paper supporting a Reactome assertion.
closed: true
ignored properties: type
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: displayLabel
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 6
  path: previousStableIdentifier
property:
  datatype: string
  description: PubMed identifier for a literature reference.
  max count: 1
  node kind: Literal
  order: 0
  path: pubmedId
  pattern: ^[0-9]+$
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: sourceSchemaClass
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeStableIdentifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 8
  path: modified
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeDbId
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 10
  path: label
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 5
  path: definition
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: identifier
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 7
  path: created
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 11
  path: description

NamedEntity
type: NodeShape
comment: Generic named entity used as a lightweight semantic root for serializable objects.
closed: false
ignored properties: hasOutput
ignored properties: endCoordinate
ignored properties: reviewed
ignored properties: identifier
ignored properties: orcid
ignored properties: precededBy
ignored properties: hasMember
ignored properties: isInDiseaseContext
ignored properties: definition
ignored properties: pubmedId
ignored properties: hasEvent
ignored properties: revised
ignored properties: catalyzes
ignored properties: sourceSchemaClass
ignored properties: hasRegulation
ignored properties: requiresComponent
ignored properties: hasModifiedResidue
ignored properties: hasCrossReference
ignored properties: url
ignored properties: hasGoCellularComponent
ignored properties: systematicName
ignored properties: hasSummation
ignored properties: isInferred
ignored properties: created
ignored properties: releaseStatus
ignored properties: reactomeStableIdentifier
ignored properties: reactomeDbId
ignored properties: supportedBy
ignored properties: hasReferenceEntity
ignored properties: releaseDate
ignored properties: hasInput
ignored properties: hasRepeatedUnit
ignored properties: sequenceReferenceType
ignored properties: hasComponent
ignored properties: hasGoMolecularFunction
ignored properties: hasInteraction
ignored properties: ncbiTaxonId
ignored properties: author
ignored properties: hasDiseaseContext
ignored properties: hasCatalyst
ignored properties: hasGoBiologicalProcess
ignored properties: identifierPrefix
ignored properties: accessUrl
ignored properties: previousStableIdentifier
ignored properties: regulates
ignored properties: modified
ignored properties: date
ignored properties: inTaxon
ignored properties: text
ignored properties: hasReactionType
ignored properties: hasCatalystActivity
ignored properties: type
ignored properties: hasActiveUnit
ignored properties: hasRegulator
ignored properties: startCoordinate
ignored properties: resourceIdentifier
ignored properties: hasInteractingEntityOnOtherCell
ignored properties: displayLabel
ignored properties: locatedInCompartment
ignored properties: hasReferenceDatabase
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 1
  path: label
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 2
  path: description
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: identifier

NegativeRegulation
type: NodeShape
comment: Regulation that decreases, inhibits, or negatively influences the occurrence or efficiency of a reaction-like event.
closed: true
ignored properties: type
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 12
  path: identifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 6
  path: sourceSchemaClass
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: displayLabel
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 14
  path: description
property:
  class: ReactionLikeEvent
  description: Reaction-like event that is the target of regulation.
  max count: 1
  min count: 1
  node kind: IRI
  order: 1
  path: regulates
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: reactomeDbId
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 10
  path: created
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 11
  path: modified
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: reactomeStableIdentifier
property:
  class: PhysicalEntity
  description: Physical entity that exerts regulatory influence on a regulated event.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasRegulator
property:
  class: PhysicalEntity
  description: Subunit, domain-bearing fragment, or active molecular portion responsible for catalytic or regulatory activity.
  node kind: IRI
  order: 2
  path: hasActiveUnit
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 13
  path: label
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 3
  path: supportedBy
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 9
  path: previousStableIdentifier
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 8
  path: definition

OtherEntity
type: NodeShape
comment: Catch-all physical entity class for biologically relevant participants not covered by more specific subclasses.
closed: true
ignored properties: type
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 13
  path: created
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 1
  path: locatedInCompartment
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 4
  path: hasGoCellularComponent
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: displayLabel
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: sourceSchemaClass
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 15
  path: identifier
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 11
  path: definition
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 17
  path: description
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 3
  path: hasDiseaseContext
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 12
  path: previousStableIdentifier
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 6
  path: isInDiseaseContext
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 0
  path: inTaxon
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: reactomeDbId
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 5
  path: systematicName
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 14
  path: modified
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 2
  path: hasCrossReference
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 16
  path: label

Pathway
type: NodeShape
comment: Curated grouping of biologically related events representing a pathway or pathway-like module.
closed: true
ignored properties: type
property:
  class: GoBiologicalProcessTerm
  description: GO biological process term associated with a Reactome pathway or event.
  max count: 1
  node kind: IRI
  order: 1
  path: hasGoBiologicalProcess
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 13
  path: reactomeDbId
property:
  class: Summation
  description: Narrative summary object explaining the biology of an event or entity.
  max count: 1
  node kind: IRI
  order: 4
  path: hasSummation
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 16
  path: displayLabel
property:
  datatype: string
  description: Editorial release state of the object in the Reactome release process.
  max count: 1
  node kind: Literal
  order: 11
  path: releaseStatus
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 3
  path: locatedInCompartment
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 18
  path: previousStableIdentifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 22
  path: label
property:
  class: InstanceEdit
  description: Provenance links to formal review actions on the object.
  node kind: IRI
  order: 8
  path: reviewed
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 15
  path: sourceSchemaClass
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 17
  path: definition
property:
  datatype: boolean
  description: Indicates whether an object was computationally inferred rather than directly curated.
  max count: 1
  node kind: Literal
  order: 12
  path: isInferred
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 21
  path: identifier
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 6
  path: hasDiseaseContext
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 23
  path: description
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 7
  path: supportedBy
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 5
  path: hasCrossReference
property:
  class: Event
  description: Membership relation linking a pathway to constituent events.
  min count: 1
  node kind: IRI
  order: 0
  path: hasEvent
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 2
  path: inTaxon
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 19
  path: created
property:
  class: InstanceEdit
  description: Provenance links to explicit revision actions after prior curation or review.
  node kind: IRI
  order: 9
  path: revised
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 20
  path: modified
property:
  datatype: date
  description: Release date associated with a curation or publication cycle.
  max count: 1
  node kind: Literal
  order: 10
  path: releaseDate
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 14
  path: reactomeStableIdentifier

Polymer
type: NodeShape
comment: Polymer entity abstracted in terms of one or more repeated units.
closed: true
ignored properties: type
property:
  class: PhysicalEntity
  description: Repeated unit composing a polymer entity.
  node kind: IRI
  order: 0
  path: hasRepeatedUnit
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 13
  path: previousStableIdentifier
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 2
  path: locatedInCompartment
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 17
  path: label
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 16
  path: identifier
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 14
  path: created
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 5
  path: hasGoCellularComponent
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 11
  path: displayLabel
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 12
  path: definition
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 7
  path: isInDiseaseContext
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 3
  path: hasCrossReference
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 4
  path: hasDiseaseContext
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: sourceSchemaClass
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 6
  path: systematicName
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 18
  path: description
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeDbId
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 1
  path: inTaxon
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 15
  path: modified

Polymerization
type: NodeShape
comment: Event representing formation of a polymer from repeated or assembling units.
closed: true
ignored properties: type
property:
  class: PhysicalEntity
  description: Physical entity consumed, transformed, or otherwise used as an input to a reaction-like event.
  node kind: IRI
  order: 0
  path: hasInput
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 13
  path: hasDiseaseContext
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 14
  path: supportedBy
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 27
  path: modified
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 28
  path: identifier
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 23
  path: displayLabel
property:
  class: PhysicalEntity
  description: Physical entity produced by a reaction-like event.
  node kind: IRI
  order: 1
  path: hasOutput
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 20
  path: reactomeDbId
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 10
  path: locatedInCompartment
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 21
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 25
  path: previousStableIdentifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 22
  path: sourceSchemaClass
property:
  class: ReactionTypeTerm
  description: Controlled reaction type annotation describing the mechanistic or editorial type of a reaction.
  node kind: IRI
  order: 8
  path: hasReactionType
property:
  class: Interaction
  description: Associated interaction object linked to an event.
  node kind: IRI
  order: 7
  path: hasInteraction
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 29
  path: label
property:
  class: InstanceEdit
  description: Provenance links to explicit revision actions after prior curation or review.
  node kind: IRI
  order: 16
  path: revised
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 24
  path: definition
property:
  datatype: date
  description: Release date associated with a curation or publication cycle.
  max count: 1
  node kind: Literal
  order: 17
  path: releaseDate
property:
  class: Summation
  description: Narrative summary object explaining the biology of an event or entity.
  max count: 1
  node kind: IRI
  order: 11
  path: hasSummation
property:
  class: Event
  description: Event that occurs before the current event in a curated process sequence.
  node kind: IRI
  order: 5
  path: precededBy
property:
  datatype: boolean
  description: Indicates whether an object was computationally inferred rather than directly curated.
  max count: 1
  node kind: Literal
  order: 19
  path: isInferred
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 30
  path: description
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 12
  path: hasCrossReference
property:
  class: CatalystActivity
  description: Catalyst activity associated with the reaction-like event.
  node kind: IRI
  order: 3
  path: hasCatalystActivity
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 26
  path: created
property:
  class: PhysicalEntity
  description: Physical entity required for a reaction-like event but not modeled as a transforming input.
  node kind: IRI
  order: 2
  path: requiresComponent
property:
  datatype: string
  description: Editorial release state of the object in the Reactome release process.
  max count: 1
  node kind: Literal
  order: 18
  path: releaseStatus
property:
  class: PhysicalEntity
  description: Physical entity located on another interacting cell in intercellular biology.
  node kind: IRI
  order: 6
  path: hasInteractingEntityOnOtherCell
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 9
  path: inTaxon
property:
  class: InstanceEdit
  description: Provenance links to formal review actions on the object.
  node kind: IRI
  order: 15
  path: reviewed

PositiveRegulation
type: NodeShape
comment: Regulation that increases, enables, or positively influences the occurrence or efficiency of a reaction-like event.
closed: true
ignored properties: type
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 11
  path: modified
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 8
  path: definition
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: displayLabel
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 13
  path: label
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 10
  path: created
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 9
  path: previousStableIdentifier
property:
  class: ReactionLikeEvent
  description: Reaction-like event that is the target of regulation.
  max count: 1
  min count: 1
  node kind: IRI
  order: 1
  path: regulates
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 14
  path: description
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: reactomeDbId
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 6
  path: sourceSchemaClass
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 3
  path: supportedBy
property:
  class: PhysicalEntity
  description: Subunit, domain-bearing fragment, or active molecular portion responsible for catalytic or regulatory activity.
  node kind: IRI
  order: 2
  path: hasActiveUnit
property:
  class: PhysicalEntity
  description: Physical entity that exerts regulatory influence on a regulated event.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasRegulator
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 12
  path: identifier

ProteinDrug
type: NodeShape
comment: Drug represented as a protein therapeutic or protein-derived biologic.
closed: true
ignored properties: type
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: reactomeDbId
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 0
  path: inTaxon
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 12
  path: previousStableIdentifier
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 1
  path: locatedInCompartment
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: displayLabel
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 11
  path: definition
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 16
  path: label
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 14
  path: modified
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 2
  path: hasCrossReference
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 6
  path: isInDiseaseContext
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 15
  path: identifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 17
  path: description
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 3
  path: hasDiseaseContext
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeStableIdentifier
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 4
  path: hasGoCellularComponent
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 5
  path: systematicName
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 13
  path: created
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: sourceSchemaClass

Reaction
type: NodeShape
comment: Standard reaction-like event with explicit transformed inputs and outputs.
closed: true
ignored properties: type
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 22
  path: sourceSchemaClass
property:
  datatype: boolean
  description: Indicates whether an object was computationally inferred rather than directly curated.
  max count: 1
  node kind: Literal
  order: 19
  path: isInferred
property:
  datatype: string
  description: Editorial release state of the object in the Reactome release process.
  max count: 1
  node kind: Literal
  order: 18
  path: releaseStatus
property:
  class: PhysicalEntity
  description: Physical entity required for a reaction-like event but not modeled as a transforming input.
  node kind: IRI
  order: 2
  path: requiresComponent
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 29
  path: label
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 24
  path: definition
property:
  class: Summation
  description: Narrative summary object explaining the biology of an event or entity.
  max count: 1
  node kind: IRI
  order: 11
  path: hasSummation
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 20
  path: reactomeDbId
property:
  class: CatalystActivity
  description: Catalyst activity associated with the reaction-like event.
  node kind: IRI
  order: 3
  path: hasCatalystActivity
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 26
  path: created
property:
  class: PhysicalEntity
  description: Physical entity produced by a reaction-like event.
  min count: 1
  node kind: IRI
  order: 1
  path: hasOutput
property:
  class: InstanceEdit
  description: Provenance links to explicit revision actions after prior curation or review.
  node kind: IRI
  order: 16
  path: revised
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 23
  path: displayLabel
property:
  class: InstanceEdit
  description: Provenance links to formal review actions on the object.
  node kind: IRI
  order: 15
  path: reviewed
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 9
  path: inTaxon
property:
  class: Regulation
  description: Reified regulation assertion attached to an event.
  node kind: IRI
  order: 4
  path: hasRegulation
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 12
  path: hasCrossReference
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 21
  path: reactomeStableIdentifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 27
  path: modified
property:
  class: PhysicalEntity
  description: Physical entity located on another interacting cell in intercellular biology.
  node kind: IRI
  order: 6
  path: hasInteractingEntityOnOtherCell
property:
  datatype: date
  description: Release date associated with a curation or publication cycle.
  max count: 1
  node kind: Literal
  order: 17
  path: releaseDate
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 14
  path: supportedBy
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 10
  path: locatedInCompartment
property:
  class: Interaction
  description: Associated interaction object linked to an event.
  node kind: IRI
  order: 7
  path: hasInteraction
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 13
  path: hasDiseaseContext
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 25
  path: previousStableIdentifier
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 28
  path: identifier
property:
  class: Event
  description: Event that occurs before the current event in a curated process sequence.
  node kind: IRI
  order: 5
  path: precededBy
property:
  class: PhysicalEntity
  description: Physical entity consumed, transformed, or otherwise used as an input to a reaction-like event.
  min count: 1
  node kind: IRI
  order: 0
  path: hasInput
property:
  class: ReactionTypeTerm
  description: Controlled reaction type annotation describing the mechanistic or editorial type of a reaction.
  node kind: IRI
  order: 8
  path: hasReactionType

ReactomeDataset
type: NodeShape
comment: Top-level container for a serialized Reactome dataset excerpt or export package.
closed: true
ignored properties: type
property:
  class: DatabaseObject
  description: Collection of Reactome objects keyed by identifier.
  node kind: IRI
  order: 0
  path: database objects

ReferenceDnaSequence
type: NodeShape
comment: Reference identity for a DNA sequence.
closed: true
ignored properties: type
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 12
  path: description
property:
  class: ReferenceDatabase
  description: Reference database authority associated with a reference entity or database identifier.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasReferenceDatabase
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: identifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 9
  path: modified
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Identifier string assigned by an external reference database.
  max count: 1
  node kind: Literal
  order: 1
  path: identifier
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: displayLabel
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 6
  path: definition
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 8
  path: created
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeDbId
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 11
  path: label
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 7
  path: previousStableIdentifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: sourceSchemaClass

ReferenceEntity
type: NodeShape
comment: Invariant reference identity used to connect multiple contextualized physical entities that share an underlying molecular identity.
closed: false
ignored properties: type
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: identifier
property:
  datatype: string
  description: Identifier string assigned by an external reference database.
  max count: 1
  node kind: Literal
  order: 1
  path: identifier
property:
  class: ReferenceDatabase
  description: Reference database authority associated with a reference entity or database identifier.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasReferenceDatabase
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 9
  path: modified
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 12
  path: description
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 8
  path: created
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 11
  path: label
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 6
  path: definition
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 7
  path: previousStableIdentifier
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: displayLabel
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeDbId
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: sourceSchemaClass

ReferenceGeneProduct
type: NodeShape
comment: Reference sequence corresponding to a gene product, typically protein-centric.
closed: true
ignored properties: type
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 11
  path: label
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 7
  path: previousStableIdentifier
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 8
  path: created
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: identifier
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 6
  path: definition
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeDbId
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 12
  path: description
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: displayLabel
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 9
  path: modified
property:
  class: ReferenceDatabase
  description: Reference database authority associated with a reference entity or database identifier.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasReferenceDatabase
property:
  datatype: string
  description: Identifier string assigned by an external reference database.
  max count: 1
  node kind: Literal
  order: 1
  path: identifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: sourceSchemaClass

ReferenceGroup
type: NodeShape
comment: Grouped reference identity used when an invariant identity is represented at a grouped rather than single-entry level.
closed: true
ignored properties: type
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 9
  path: modified
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: displayLabel
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 8
  path: created
property:
  datatype: string
  description: Identifier string assigned by an external reference database.
  max count: 1
  node kind: Literal
  order: 1
  path: identifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeDbId
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 11
  path: label
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 6
  path: definition
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 12
  path: description
property:
  class: ReferenceDatabase
  description: Reference database authority associated with a reference entity or database identifier.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasReferenceDatabase
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: sourceSchemaClass
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: identifier
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 7
  path: previousStableIdentifier
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: reactomeStableIdentifier

ReferenceIsoform
type: NodeShape
comment: Reference sequence representing a specific isoform-level identity.
closed: true
ignored properties: type
property:
  datatype: string
  description: Identifier string assigned by an external reference database.
  max count: 1
  node kind: Literal
  order: 1
  path: identifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 11
  path: label
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 9
  path: modified
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 6
  path: definition
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 7
  path: previousStableIdentifier
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: identifier
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 8
  path: created
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 12
  path: description
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: displayLabel
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: sourceSchemaClass
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: reactomeStableIdentifier
property:
  class: ReferenceDatabase
  description: Reference database authority associated with a reference entity or database identifier.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasReferenceDatabase
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeDbId

ReferenceRnaSequence
type: NodeShape
comment: Reference identity for an RNA sequence.
closed: true
ignored properties: type
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 9
  path: modified
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: sourceSchemaClass
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 12
  path: description
property:
  datatype: string
  description: Identifier string assigned by an external reference database.
  max count: 1
  node kind: Literal
  order: 1
  path: identifier
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: displayLabel
property:
  class: ReferenceDatabase
  description: Reference database authority associated with a reference entity or database identifier.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasReferenceDatabase
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 7
  path: previousStableIdentifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeDbId
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 8
  path: created
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: identifier
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 6
  path: definition
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 11
  path: label

ReferenceTherapeutic
type: NodeShape
comment: Reference identity for a therapeutic or intervention-oriented entity.
closed: true
ignored properties: type
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: displayLabel
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: identifier
property:
  datatype: string
  description: Identifier string assigned by an external reference database.
  max count: 1
  node kind: Literal
  order: 1
  path: identifier
property:
  class: ReferenceDatabase
  description: Reference database authority associated with a reference entity or database identifier.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasReferenceDatabase
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: sourceSchemaClass
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 8
  path: created
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 6
  path: definition
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 9
  path: modified
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 11
  path: label
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 7
  path: previousStableIdentifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeDbId
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 12
  path: description

Requirement
type: NodeShape
comment: Regulation-like assertion indicating that a regulator or participant is required for a reaction-like event to occur.
closed: true
ignored properties: type
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 3
  path: supportedBy
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 6
  path: sourceSchemaClass
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 14
  path: description
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 9
  path: previousStableIdentifier
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 12
  path: identifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: reactomeDbId
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: reactomeStableIdentifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 11
  path: modified
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: displayLabel
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 10
  path: created
property:
  class: PhysicalEntity
  description: Physical entity that exerts regulatory influence on a regulated event.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasRegulator
property:
  class: PhysicalEntity
  description: Subunit, domain-bearing fragment, or active molecular portion responsible for catalytic or regulatory activity.
  node kind: IRI
  order: 2
  path: hasActiveUnit
property:
  class: ReactionLikeEvent
  description: Reaction-like event that is the target of regulation.
  max count: 1
  min count: 1
  node kind: IRI
  order: 1
  path: regulates
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 13
  path: label
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 8
  path: definition

RnaDrug
type: NodeShape
comment: Drug represented as an RNA-based therapeutic agent.
closed: true
ignored properties: type
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 5
  path: systematicName
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 6
  path: isInDiseaseContext
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: displayLabel
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeStableIdentifier
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 4
  path: hasGoCellularComponent
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 3
  path: hasDiseaseContext
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 1
  path: locatedInCompartment
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 11
  path: definition
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 0
  path: inTaxon
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 17
  path: description
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 12
  path: previousStableIdentifier
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 2
  path: hasCrossReference
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: reactomeDbId
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 13
  path: created
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 14
  path: modified
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 16
  path: label
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 15
  path: identifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: sourceSchemaClass

SequenceEntity
type: NodeShape
comment: Sequence-bearing physical entity linked to a stable reference sequence and optionally decorated with residue modifications and subsequence coordinates.
closed: true
ignored properties: type
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 6
  path: locatedInCompartment
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 9
  path: hasGoCellularComponent
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 13
  path: reactomeStableIdentifier
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 8
  path: hasDiseaseContext
property:
  datatype: integer
  description: End coordinate of a subsequence, fragment, or feature-bearing region on a sequence entity.
  max count: 1
  node kind: Literal
  order: 3
  path: endCoordinate
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 21
  path: label
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 5
  path: inTaxon
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 10
  path: systematicName
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 18
  path: created
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 17
  path: previousStableIdentifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 22
  path: description
property:
  class: ReferenceSequence
  description: Invariant reference identity underlying a contextualized physical entity.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasReferenceEntity
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 14
  path: sourceSchemaClass
property:
  class: AbstractModifiedResidue
  description: Modified residue feature borne by a sequence-based physical entity.
  node kind: IRI
  order: 1
  path: hasModifiedResidue
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 11
  path: isInDiseaseContext
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 16
  path: definition
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 20
  path: identifier
property:
  datatype: integer
  description: Start coordinate of a subsequence, fragment, or feature-bearing region on a sequence entity.
  max count: 1
  node kind: Literal
  order: 2
  path: startCoordinate
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 19
  path: modified
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 7
  path: hasCrossReference
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 12
  path: reactomeDbId
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 15
  path: displayLabel
property:
  datatype: string
  description: Textual qualifier for the kind of referenced sequence or entity.
  max count: 1
  node kind: Literal
  order: 4
  path: sequenceReferenceType

SimpleEntity
type: NodeShape
comment: Simple molecular entity, typically a small molecule or other non-sequence-based chemical participant.
closed: true
ignored properties: type
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: reactomeStableIdentifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeDbId
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 15
  path: modified
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 17
  path: label
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 13
  path: previousStableIdentifier
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 3
  path: hasCrossReference
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 6
  path: systematicName
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 7
  path: isInDiseaseContext
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 16
  path: identifier
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 1
  path: inTaxon
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 11
  path: displayLabel
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 5
  path: hasGoCellularComponent
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 4
  path: hasDiseaseContext
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 18
  path: description
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 14
  path: created
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 2
  path: locatedInCompartment
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: sourceSchemaClass
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 12
  path: definition
property:
  class: ReferenceMolecule
  description: Invariant reference identity underlying a contextualized physical entity.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasReferenceEntity

Taxon
type: NodeShape
comment: Taxonomic concept used for taxonomic assignment or metadata.
closed: true
ignored properties: type
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeDbId
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 7
  path: created
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: sourceSchemaClass
property:
  datatype: string
  description: Taxonomic identifier, typically aligned to the NCBI Taxonomy.
  max count: 1
  node kind: Literal
  order: 0
  path: ncbiTaxonId
  pattern: ^[0-9]+$
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: displayLabel
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 8
  path: modified
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 5
  path: definition
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 11
  path: description
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 10
  path: label
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 6
  path: previousStableIdentifier
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: identifier

AbstractModifiedResidue
type: NodeShape
comment: Feature record describing a modified residue or residue-level state on a sequence-bearing entity.
closed: true
ignored properties: type
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: displayLabel
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 4
  path: definition
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: reactomeDbId
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: identifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 10
  path: description
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 9
  path: label
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 5
  path: previousStableIdentifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: sourceSchemaClass
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 7
  path: modified
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 6
  path: created

DatabaseObject
type: NodeShape
comment: Root class for most Reactome schema objects and the main provenance-bearing superclass.
closed: true
ignored properties: hasOutput
ignored properties: endCoordinate
ignored properties: reviewed
ignored properties: identifier
ignored properties: orcid
ignored properties: precededBy
ignored properties: hasMember
ignored properties: isInDiseaseContext
ignored properties: pubmedId
ignored properties: hasEvent
ignored properties: revised
ignored properties: catalyzes
ignored properties: hasRegulation
ignored properties: requiresComponent
ignored properties: hasModifiedResidue
ignored properties: hasCrossReference
ignored properties: url
ignored properties: hasGoCellularComponent
ignored properties: systematicName
ignored properties: hasSummation
ignored properties: isInferred
ignored properties: releaseStatus
ignored properties: supportedBy
ignored properties: hasReferenceEntity
ignored properties: releaseDate
ignored properties: hasInput
ignored properties: hasRepeatedUnit
ignored properties: sequenceReferenceType
ignored properties: hasComponent
ignored properties: hasGoMolecularFunction
ignored properties: hasInteraction
ignored properties: ncbiTaxonId
ignored properties: author
ignored properties: hasDiseaseContext
ignored properties: hasCatalyst
ignored properties: hasGoBiologicalProcess
ignored properties: identifierPrefix
ignored properties: accessUrl
ignored properties: regulates
ignored properties: date
ignored properties: inTaxon
ignored properties: text
ignored properties: hasReactionType
ignored properties: hasCatalystActivity
ignored properties: type
ignored properties: hasActiveUnit
ignored properties: hasRegulator
ignored properties: startCoordinate
ignored properties: resourceIdentifier
ignored properties: hasInteractingEntityOnOtherCell
ignored properties: locatedInCompartment
ignored properties: hasReferenceDatabase
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 5
  path: previousStableIdentifier
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 4
  path: definition
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 10
  path: description
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 6
  path: created
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: displayLabel
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: reactomeDbId
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 9
  path: label
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: identifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: sourceSchemaClass
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 7
  path: modified
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeStableIdentifier

GoBiologicalProcessTerm
type: NodeShape
comment: Wrapper object for a GO biological process term used for pathway or event alignment.
closed: true
ignored properties: type
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 9
  path: label
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: displayLabel
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 7
  path: modified
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 4
  path: definition
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: reactomeDbId
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: identifier
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 5
  path: previousStableIdentifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 10
  path: description
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: sourceSchemaClass
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeStableIdentifier
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 6
  path: created

GoMolecularFunctionTerm
type: NodeShape
comment: Wrapper object for a GO molecular function term used in Reactome catalysis modeling.
closed: true
ignored properties: type
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 6
  path: created
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: identifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 10
  path: description
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 9
  path: label
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 4
  path: definition
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: sourceSchemaClass
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: displayLabel
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 5
  path: previousStableIdentifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 7
  path: modified
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: reactomeDbId

Person
type: NodeShape
comment: Person record used primarily for provenance, authorship, and curation attribution.
closed: true
ignored properties: type
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: identifier
property:
  datatype: anyURI
  description: ORCID identifier for a person involved in curation or authorship.
  max count: 1
  node kind: Literal
  order: 0
  path: orcid
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeDbId
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 8
  path: modified
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 5
  path: definition
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 10
  path: label
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: displayLabel
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 11
  path: description
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: sourceSchemaClass
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 7
  path: created
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 6
  path: previousStableIdentifier

ReferenceMolecule
type: NodeShape
comment: Reference identity for a small molecule, simple chemical, or chemically grounded participant.
closed: true
ignored properties: type
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 11
  path: label
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 6
  path: definition
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 9
  path: modified
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 8
  path: created
property:
  datatype: string
  description: Identifier string assigned by an external reference database.
  max count: 1
  node kind: Literal
  order: 1
  path: identifier
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 7
  path: previousStableIdentifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeDbId
property:
  class: ReferenceDatabase
  description: Reference database authority associated with a reference entity or database identifier.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasReferenceDatabase
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 12
  path: description
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: identifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: sourceSchemaClass
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: displayLabel

ReferenceSequence
type: NodeShape
comment: Reference identity for a sequence-bearing biomolecule.
closed: true
ignored properties: type
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 9
  path: modified
property:
  class: ReferenceDatabase
  description: Reference database authority associated with a reference entity or database identifier.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasReferenceDatabase
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: identifier
property:
  datatype: string
  description: Identifier string assigned by an external reference database.
  max count: 1
  node kind: Literal
  order: 1
  path: identifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 11
  path: label
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 7
  path: previousStableIdentifier
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: reactomeStableIdentifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeDbId
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 12
  path: description
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 8
  path: created
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: displayLabel
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: sourceSchemaClass
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 6
  path: definition

CatalystActivity
type: NodeShape
comment: Reified catalytic assertion connecting a catalyst bearer, a GO molecular function, and one or more catalyzed reaction-like events.
closed: true
ignored properties: type
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 4
  path: supportedBy
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 14
  path: label
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: displayLabel
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: reactomeDbId
property:
  class: PhysicalEntity
  description: Subunit, domain-bearing fragment, or active molecular portion responsible for catalytic or regulatory activity.
  node kind: IRI
  order: 2
  path: hasActiveUnit
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 15
  path: description
property:
  class: ReactionLikeEvent
  description: Reaction-like event catalyzed by the given catalyst activity.
  node kind: IRI
  order: 3
  path: catalyzes
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 10
  path: previousStableIdentifier
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 11
  path: created
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 12
  path: modified
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: sourceSchemaClass
property:
  class: GoMolecularFunctionTerm
  description: GO molecular function term asserted in a catalyst activity.
  max count: 1
  min count: 1
  node kind: IRI
  order: 1
  path: hasGoMolecularFunction
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 9
  path: definition
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 6
  path: reactomeStableIdentifier
property:
  class: PhysicalEntity
  description: Physical entity serving as the bearer of a catalyst activity.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasCatalyst
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 13
  path: identifier

Interaction
type: NodeShape
comment: Interaction record associated with an event or set of participants.
closed: true
ignored properties: type
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 7
  path: modified
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: identifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: reactomeDbId
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 9
  path: label
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: sourceSchemaClass
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: displayLabel
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 6
  path: created
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 10
  path: description
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 5
  path: previousStableIdentifier
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 4
  path: definition

ReactionLikeEvent
type: NodeShape
comment: Event in which physical entities participate as inputs, outputs, regulators, or catalysts in a transformation-like process.
closed: false
ignored properties: type
property:
  datatype: string
  description: Editorial release state of the object in the Reactome release process.
  max count: 1
  node kind: Literal
  order: 18
  path: releaseStatus
property:
  class: PhysicalEntity
  description: Physical entity produced by a reaction-like event.
  node kind: IRI
  order: 1
  path: hasOutput
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 10
  path: locatedInCompartment
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 28
  path: identifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 29
  path: label
property:
  class: PhysicalEntity
  description: Physical entity located on another interacting cell in intercellular biology.
  node kind: IRI
  order: 6
  path: hasInteractingEntityOnOtherCell
property:
  class: PhysicalEntity
  description: Physical entity required for a reaction-like event but not modeled as a transforming input.
  node kind: IRI
  order: 2
  path: requiresComponent
property:
  class: Event
  description: Event that occurs before the current event in a curated process sequence.
  node kind: IRI
  order: 5
  path: precededBy
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 21
  path: reactomeStableIdentifier
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 14
  path: supportedBy
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 13
  path: hasDiseaseContext
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 30
  path: description
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 23
  path: displayLabel
property:
  class: PhysicalEntity
  description: Physical entity consumed, transformed, or otherwise used as an input to a reaction-like event.
  node kind: IRI
  order: 0
  path: hasInput
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 20
  path: reactomeDbId
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 12
  path: hasCrossReference
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 27
  path: modified
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 24
  path: definition
property:
  class: CatalystActivity
  description: Catalyst activity associated with the reaction-like event.
  node kind: IRI
  order: 3
  path: hasCatalystActivity
property:
  class: Interaction
  description: Associated interaction object linked to an event.
  node kind: IRI
  order: 7
  path: hasInteraction
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 26
  path: created
property:
  class: Summation
  description: Narrative summary object explaining the biology of an event or entity.
  max count: 1
  node kind: IRI
  order: 11
  path: hasSummation
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 25
  path: previousStableIdentifier
property:
  class: InstanceEdit
  description: Provenance links to explicit revision actions after prior curation or review.
  node kind: IRI
  order: 16
  path: revised
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 22
  path: sourceSchemaClass
property:
  datatype: date
  description: Release date associated with a curation or publication cycle.
  max count: 1
  node kind: Literal
  order: 17
  path: releaseDate
property:
  datatype: boolean
  description: Indicates whether an object was computationally inferred rather than directly curated.
  max count: 1
  node kind: Literal
  order: 19
  path: isInferred
property:
  class: ReactionTypeTerm
  description: Controlled reaction type annotation describing the mechanistic or editorial type of a reaction.
  node kind: IRI
  order: 8
  path: hasReactionType
property:
  class: Regulation
  description: Reified regulation assertion attached to an event.
  node kind: IRI
  order: 4
  path: hasRegulation
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 9
  path: inTaxon

ReactionTypeTerm
type: NodeShape
comment: Controlled vocabulary term used to characterize a reaction-like event.
closed: true
ignored properties: type
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 9
  path: label
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 6
  path: created
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: identifier
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeStableIdentifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: reactomeDbId
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 10
  path: description
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 4
  path: definition
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: displayLabel
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 7
  path: modified
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 5
  path: previousStableIdentifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: sourceSchemaClass

Regulation
type: NodeShape
comment: Reified regulatory assertion linking a regulator physical entity to a regulated reaction-like event.
closed: false
ignored properties: type
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: displayLabel
property:
  class: PhysicalEntity
  description: Subunit, domain-bearing fragment, or active molecular portion responsible for catalytic or regulatory activity.
  node kind: IRI
  order: 2
  path: hasActiveUnit
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: reactomeDbId
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 9
  path: previousStableIdentifier
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 3
  path: supportedBy
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 13
  path: label
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 8
  path: definition
property:
  class: PhysicalEntity
  description: Physical entity that exerts regulatory influence on a regulated event.
  max count: 1
  min count: 1
  node kind: IRI
  order: 0
  path: hasRegulator
property:
  class: ReactionLikeEvent
  description: Reaction-like event that is the target of regulation.
  max count: 1
  min count: 1
  node kind: IRI
  order: 1
  path: regulates
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 14
  path: description
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 12
  path: identifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 11
  path: modified
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 6
  path: sourceSchemaClass
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 10
  path: created

Event
type: NodeShape
comment: Biological occurrence or process unit in Reactome, covering both pathways and reaction-like events.
closed: false
ignored properties: hasOutput
ignored properties: hasReactionType
ignored properties: hasInput
ignored properties: hasCatalystActivity
ignored properties: hasInteractingEntityOnOtherCell
ignored properties: type
ignored properties: hasInteraction
ignored properties: precededBy
ignored properties: hasEvent
ignored properties: hasGoBiologicalProcess
ignored properties: hasRegulation
ignored properties: requiresComponent
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 1
  path: locatedInCompartment
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 4
  path: hasDiseaseContext
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 21
  path: description
property:
  class: Publication
  description: Publication supporting the existence, mechanism, or curation of the object.
  node kind: IRI
  order: 5
  path: supportedBy
property:
  class: InstanceEdit
  description: Provenance links to formal review actions on the object.
  node kind: IRI
  order: 6
  path: reviewed
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 20
  path: label
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 13
  path: sourceSchemaClass
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 15
  path: definition
property:
  datatype: string
  description: Editorial release state of the object in the Reactome release process.
  max count: 1
  node kind: Literal
  order: 9
  path: releaseStatus
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 11
  path: reactomeDbId
property:
  datatype: boolean
  description: Indicates whether an object was computationally inferred rather than directly curated.
  max count: 1
  node kind: Literal
  order: 10
  path: isInferred
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 12
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 16
  path: previousStableIdentifier
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 17
  path: created
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 0
  path: inTaxon
property:
  class: InstanceEdit
  description: Provenance links to explicit revision actions after prior curation or review.
  node kind: IRI
  order: 7
  path: revised
property:
  datatype: date
  description: Release date associated with a curation or publication cycle.
  max count: 1
  node kind: Literal
  order: 8
  path: releaseDate
property:
  class: Summation
  description: Narrative summary object explaining the biology of an event or entity.
  max count: 1
  node kind: IRI
  order: 2
  path: hasSummation
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 3
  path: hasCrossReference
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 19
  path: identifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 18
  path: modified
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 14
  path: displayLabel

Summation
type: NodeShape
comment: Narrative summary record containing prose that explains the biological meaning of an entity or event.
closed: true
ignored properties: type
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 7
  path: created
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 10
  path: label
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: sourceSchemaClass
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 5
  path: definition
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: displayLabel
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: identifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 11
  path: description
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 8
  path: modified
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeStableIdentifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeDbId
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 6
  path: previousStableIdentifier
property:
  datatype: string
  description: Narrative summary text.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: text

ReferenceDatabase
type: NodeShape
comment: Metadata record describing an external database or authority used for identifiers and cross-references.
closed: true
ignored properties: type
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 12
  path: identifier
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 14
  path: description
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 13
  path: label
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 9
  path: previousStableIdentifier
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 8
  path: definition
property:
  datatype: anyURI
  description: General URL associated with an object.
  max count: 1
  node kind: Literal
  order: 3
  path: url
property:
  datatype: anyURI
  description: URL template or access URL used to resolve an identifier in a reference database.
  max count: 1
  node kind: Literal
  order: 0
  path: accessUrl
property:
  datatype: string
  description: Identifier for the reference resource itself rather than for entries inside it.
  max count: 1
  node kind: Literal
  order: 2
  path: resourceIdentifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 6
  path: sourceSchemaClass
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 11
  path: modified
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 10
  path: created
property:
  datatype: string
  description: Prefix or namespace abbreviation used by a reference database.
  max count: 1
  node kind: Literal
  order: 1
  path: identifierPrefix
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: reactomeDbId
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: displayLabel

Publication
type: NodeShape
comment: Publication record used as evidence or supporting documentation for curated biology.
closed: false
ignored properties: pubmedId
ignored properties: type
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 9
  path: label
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: reactomeDbId
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: identifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: sourceSchemaClass
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 6
  path: created
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 4
  path: definition
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 7
  path: modified
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 5
  path: previousStableIdentifier
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: displayLabel
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 10
  path: description
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeStableIdentifier

GoCellularComponentTerm
type: NodeShape
comment: Wrapper object for a GO cellular component term used in entity or location annotation.
closed: true
ignored properties: type
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 5
  path: previousStableIdentifier
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: displayLabel
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: identifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 10
  path: description
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 4
  path: definition
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 9
  path: label
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: sourceSchemaClass
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 7
  path: modified
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 6
  path: created
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: reactomeDbId

Compartment
type: NodeShape
comment: Cellular or subcellular location object used to state where an event occurs or where a physical entity resides.
closed: true
ignored properties: type
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 10
  path: description
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 7
  path: modified
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 9
  path: label
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 6
  path: created
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 5
  path: previousStableIdentifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: sourceSchemaClass
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: identifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: reactomeDbId
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 4
  path: definition
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: displayLabel

DatabaseIdentifier
type: NodeShape
comment: Cross-reference record that pairs an identifier string with a reference database authority.
closed: true
ignored properties: type
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 9
  path: modified
property:
  class: ReferenceDatabase
  description: Reference database authority associated with a reference entity or database identifier.
  max count: 1
  node kind: IRI
  order: 1
  path: hasReferenceDatabase
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: sourceSchemaClass
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 7
  path: previousStableIdentifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 12
  path: description
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 11
  path: label
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: displayLabel
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 8
  path: created
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: identifier
property:
  datatype: string
  description: Identifier string assigned by an external reference database.
  max count: 1
  node kind: Literal
  order: 0
  path: identifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeDbId
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 6
  path: definition

Disease
type: NodeShape
comment: Disease concept used to contextualize events and entities in pathological settings.
closed: true
ignored properties: type
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: sourceSchemaClass
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: identifier
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: displayLabel
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 10
  path: description
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 4
  path: definition
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 0
  path: reactomeDbId
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 6
  path: created
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 5
  path: previousStableIdentifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 7
  path: modified
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 9
  path: label

OrganismTaxon
type: NodeShape
comment: Organism taxon record representing the organismal context for entities and events.
closed: true
ignored properties: type
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 11
  path: description
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 10
  path: label
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 5
  path: definition
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: displayLabel
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 6
  path: previousStableIdentifier
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: sourceSchemaClass
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: identifier
property:
  datatype: string
  description: Taxonomic identifier, typically aligned to the NCBI Taxonomy.
  max count: 1
  node kind: Literal
  order: 0
  path: ncbiTaxonId
  pattern: ^[0-9]+$
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 1
  path: reactomeDbId
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeStableIdentifier
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 8
  path: modified
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 7
  path: created

PhysicalEntity
type: NodeShape
comment: Concrete biological participant whose identity reflects both underlying molecular identity and contextual state.
closed: false
ignored properties: endCoordinate
ignored properties: hasReferenceEntity
ignored properties: hasRepeatedUnit
ignored properties: sequenceReferenceType
ignored properties: hasComponent
ignored properties: type
ignored properties: hasMember
ignored properties: startCoordinate
ignored properties: hasModifiedResidue
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 11
  path: definition
property:
  class: Compartment
  description: Compartment in which an entity resides or an event occurs.
  node kind: IRI
  order: 1
  path: locatedInCompartment
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 13
  path: created
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: displayLabel
property:
  class: DatabaseIdentifier
  description: External cross-reference to another database or controlled resource.
  node kind: IRI
  order: 2
  path: hasCrossReference
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 17
  path: description
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 16
  path: label
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 12
  path: previousStableIdentifier
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 7
  path: reactomeDbId
property:
  datatype: string
  description: Formal or systematic name for an entity when available.
  max count: 1
  node kind: Literal
  order: 5
  path: systematicName
property:
  class: Disease
  description: Disease context associated with an event or physical entity.
  node kind: IRI
  order: 3
  path: hasDiseaseContext
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 9
  path: sourceSchemaClass
property:
  class: OrganismTaxon
  description: Taxon in which the object, event, or entity is asserted to occur or be defined.
  node kind: IRI
  order: 0
  path: inTaxon
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 14
  path: modified
property:
  class: GoCellularComponentTerm
  description: GO cellular component term associated with a physical entity or event context.
  max count: 1
  node kind: IRI
  order: 4
  path: hasGoCellularComponent
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 8
  path: reactomeStableIdentifier
property:
  datatype: boolean
  description: Boolean flag indicating that the represented entity is contextualized to a disease state.
  max count: 1
  node kind: Literal
  order: 6
  path: isInDiseaseContext
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 15
  path: identifier

InstanceEdit
type: NodeShape
comment: Provenance record describing a curation action such as creation, modification, review, or revision.
closed: true
ignored properties: type
property:
  datatype: string
  description: Stable public Reactome identifier for an object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 3
  path: reactomeStableIdentifier
property:
  datatype: string
  description: Human-readable primary label for an object.
  max count: 1
  node kind: Literal
  order: 11
  path: label
property:
  datatype: integer
  description: Internal Reactome database identifier assigned to a database object.
  max count: 1
  min count: 1
  node kind: Literal
  order: 2
  path: reactomeDbId
property:
  datatype: string
  description: Free-text textual description of an object.
  max count: 1
  node kind: Literal
  order: 12
  path: description
property:
  class: InstanceEdit
  description: Provenance links to subsequent modifications of the object record.
  node kind: IRI
  order: 9
  path: modified
property:
  datatype: string
  description: Name of the source Reactome schema class from which the instance derives.
  max count: 1
  min count: 1
  node kind: Literal
  order: 4
  path: sourceSchemaClass
property:
  datatype: string
  description: Curated textual definition that states what the object is.
  max count: 1
  node kind: Literal
  order: 6
  path: definition
property:
  class: Person
  description: Person or people responsible for the edit activity.
  node kind: IRI
  order: 1
  path: author
property:
  datatype: string
  description: Preferred display label used by Reactome for user-facing presentation.
  max count: 1
  min count: 1
  node kind: Literal
  order: 5
  path: displayLabel
property:
  datatype: string
  description: Unique identifier for an instance in the serialized dataset.
  max count: 1
  min count: 1
  node kind: Literal
  order: 10
  path: identifier
property:
  class: InstanceEdit
  description: Provenance link to the curation event that originally created the object record.
  max count: 1
  min count: 1
  node kind: IRI
  order: 8
  path: created
property:
  datatype: dateTime
  description: Timestamp or date string for the edit activity.
  max count: 1
  node kind: Literal
  order: 0
  path: date
property:
  datatype: string
  description: Deprecated or previous stable Reactome identifier retained for traceability.
  max count: 1
  node kind: Literal
  order: 7
  path: previousStableIdentifier

datatype: string
description: Deprecated or previous stable Reactome identifier retained for traceability.
max count: 1
node kind: Literal
order: 25
path: previousStableIdentifier

class: Regulation
description: Reified regulation assertion attached to an event.
node kind: IRI
order: 4
path: hasRegulation

class: Regulation
description: Reified regulation assertion attached to an event.
node kind: IRI
order: 4
path: hasRegulation

datatype: string
description: Free-text textual description of an object.
max count: 1
node kind: Literal
order: 30
path: description

class: InstanceEdit
description: Provenance links to formal review actions on the object.
node kind: IRI
order: 15
path: reviewed