Reaction-like event included in the pathway model despite incomplete mechanistic detail.
Controlled reaction type annotation describing the mechanistic or editorial type of a reaction.
Physical entity required for a reaction-like event but not modeled as a transforming input.
Physical entity located on another interacting cell in intercellular biology.
Event that occurs before the current event in a curated process sequence.
External cross-reference to another database or controlled resource.
Free-text textual description of an object.
Associated interaction object linked to an event.
Publication supporting the existence, mechanism, or curation of the object.
Provenance links to explicit revision actions after prior curation or review.
Preferred display label used by Reactome for user-facing presentation.
Narrative summary object explaining the biology of an event or entity.
Provenance links to subsequent modifications of the object record.
Physical entity produced by a reaction-like event.
Curated textual definition that states what the object is.
Reified regulation assertion attached to an event.
Release date associated with a curation or publication cycle.
Compartment in which an entity resides or an event occurs.
Internal Reactome database identifier assigned to a database object.
Unique identifier for an instance in the serialized dataset.
Provenance links to formal review actions on the object.
Indicates whether an object was computationally inferred rather than directly curated.
Stable public Reactome identifier for an object.
Catalyst activity associated with the reaction-like event.
Disease context associated with an event or physical entity.
Human-readable primary label for an object.
Name of the source Reactome schema class from which the instance derives.
Editorial release state of the object in the Reactome release process.
Provenance link to the curation event that originally created the object record.
Taxon in which the object, event, or entity is asserted to occur or be defined.
Physical entity consumed, transformed, or otherwise used as an input to a reaction-like event.
Deprecated or previous stable Reactome identifier retained for traceability.
Entity set whose members are candidates for fulfilling a shared biological role.
Formal or systematic name for an entity when available.
Members of an entity set representing functionally interchangeable participants.
GO cellular component term associated with a physical entity or event context.
Boolean flag indicating that the represented entity is contextualized to a disease state.
Cell or cell-like biological unit treated as a physical participant in an event.
Drug represented primarily as a chemical or small-molecule therapeutic agent.
Physical entity composed of two or more component physical entities assembled into a functional complex.
Component physical entities that make up a complex.
Entity set whose members are explicitly curated as the intended interchangeable participants.
Event representing breakdown of a polymer into constituent or smaller units.
Therapeutic or intervention-oriented physical entity modeled in the Reactome graph.
Curated set of physical entities that are treated as functionally interchangeable in a given biological context.
Physical entity whose existence is grounded in a genome-encoded product such as a protein or nucleic acid.
Literature citation record, commonly representing a PubMed-indexed paper supporting a Reactome assertion.
PubMed identifier for a literature reference.
Generic named entity used as a lightweight semantic root for serializable objects.
Regulation that decreases, inhibits, or negatively influences the occurrence or efficiency of a reaction-like event.
Reaction-like event that is the target of regulation.
Physical entity that exerts regulatory influence on a regulated event.
Subunit, domain-bearing fragment, or active molecular portion responsible for catalytic or regulatory activity.
Catch-all physical entity class for biologically relevant participants not covered by more specific subclasses.
Curated grouping of biologically related events representing a pathway or pathway-like module.
GO biological process term associated with a Reactome pathway or event.
Membership relation linking a pathway to constituent events.
Polymer entity abstracted in terms of one or more repeated units.
Repeated unit composing a polymer entity.
Event representing formation of a polymer from repeated or assembling units.
Regulation that increases, enables, or positively influences the occurrence or efficiency of a reaction-like event.
Drug represented as a protein therapeutic or protein-derived biologic.
Standard reaction-like event with explicit transformed inputs and outputs.
Top-level container for a serialized Reactome dataset excerpt or export package.
Collection of Reactome objects keyed by identifier.
Reference database authority associated with a reference entity or database identifier.
Identifier string assigned by an external reference database.
Invariant reference identity used to connect multiple contextualized physical entities that share an underlying molecular identity.
Reference sequence corresponding to a gene product, typically protein-centric.
Grouped reference identity used when an invariant identity is represented at a grouped rather than single-entry level.
Reference sequence representing a specific isoform-level identity.
Reference identity for a therapeutic or intervention-oriented entity.
Regulation-like assertion indicating that a regulator or participant is required for a reaction-like event to occur.
Drug represented as an RNA-based therapeutic agent.
Sequence-bearing physical entity linked to a stable reference sequence and optionally decorated with residue modifications and subsequence coordinates.
End coordinate of a subsequence, fragment, or feature-bearing region on a sequence entity.
Invariant reference identity underlying a contextualized physical entity.
Modified residue feature borne by a sequence-based physical entity.
Start coordinate of a subsequence, fragment, or feature-bearing region on a sequence entity.
Textual qualifier for the kind of referenced sequence or entity.
Simple molecular entity, typically a small molecule or other non-sequence-based chemical participant.
Taxonomic concept used for taxonomic assignment or metadata.
Taxonomic identifier, typically aligned to the NCBI Taxonomy.
Feature record describing a modified residue or residue-level state on a sequence-bearing entity.
Root class for most Reactome schema objects and the main provenance-bearing superclass.
Wrapper object for a GO biological process term used for pathway or event alignment.
Wrapper object for a GO molecular function term used in Reactome catalysis modeling.
Person record used primarily for provenance, authorship, and curation attribution.
ORCID identifier for a person involved in curation or authorship.
Reference identity for a small molecule, simple chemical, or chemically grounded participant.
Reference identity for a sequence-bearing biomolecule.
Reified catalytic assertion connecting a catalyst bearer, a GO molecular function, and one or more catalyzed reaction-like events.
Reaction-like event catalyzed by the given catalyst activity.
GO molecular function term asserted in a catalyst activity.
Physical entity serving as the bearer of a catalyst activity.
Interaction record associated with an event or set of participants.
Event in which physical entities participate as inputs, outputs, regulators, or catalysts in a transformation-like process.
Controlled vocabulary term used to characterize a reaction-like event.
Reified regulatory assertion linking a regulator physical entity to a regulated reaction-like event.
Biological occurrence or process unit in Reactome, covering both pathways and reaction-like events.
Narrative summary record containing prose that explains the biological meaning of an entity or event.
Metadata record describing an external database or authority used for identifiers and cross-references.
URL template or access URL used to resolve an identifier in a reference database.
Identifier for the reference resource itself rather than for entries inside it.
Prefix or namespace abbreviation used by a reference database.
Publication record used as evidence or supporting documentation for curated biology.
Wrapper object for a GO cellular component term used in entity or location annotation.
Cellular or subcellular location object used to state where an event occurs or where a physical entity resides.
Cross-reference record that pairs an identifier string with a reference database authority.
Disease concept used to contextualize events and entities in pathological settings.
Organism taxon record representing the organismal context for entities and events.
Concrete biological participant whose identity reflects both underlying molecular identity and contextual state.
Provenance record describing a curation action such as creation, modification, review, or revision.
Person or people responsible for the edit activity.
Timestamp or date string for the edit activity.